The unmeasured burden: Contribution of depression and psychological stress to patient-reported outcomes in atrial fibrillation

• Published in: International journal of cardiology 2020-03, Vol.302, p.75-80
• Main Authors: Gisi, Brittany, Althouse, Andrew D., Mathier, Abigail S., Pusateri, Alexandra, Rollman, Bruce L., LaRosa, Anna, Magnani, Jared W.
• Format: Article
• Language: English
• Subjects: Aged; Atrial fibrillation; Atrial Fibrillation - complications; Atrial Fibrillation - psychology; Depression; Depression - etiology; Depression - psychology; Disease Progression; Female; Humans; Male; Patient Reported Outcome Measures; Patient-reported outcomes; Quality of Life; Risk Factors; Stress; Stress, Psychological - complications; Stress, Psychological - psychology
• ISSN: 0167-5273; 1874-1754
• DOI: 10.1016/j.ijcard.2019.12.004

Patient-reported outcomes are routinely assessed in atrial fibrillation (AF) to evaluate efficacy of treatment and as clinical trial outcomes. The relation of depression to such measures has had limited study in AF. In a cohort receiving treatment for AF, we assessed depression with the Patient Health Questionniare-9 (PHQ; 0–4, normal range; 5–9, mild depression; ≥10 moderate depression). We related depression to disease-specific quality of life with the AF Effect on QualiTy of life (AFEQT, range 0–100) and the Global Perceived Stress Scale (GPPS, range 0–24) in multivariable-adjusted models. In 260 individuals (age 71.7 ± 10.1, 44.6% women) with AF, 51 (26.1%) had PHQ scores ≥5 and 17 (6.5%) ≥10. AFEQT scores decreased progressively with depression severity (normal range PHQ, 81.4 ± 14.1; mild depression, 65.8 ± 17.1; moderate depression, 50.6 ± 19.3). Individuals without depression had lower GPPS scores (3.0 ± 2.6) than those with mild (4.9 ± 2.5) or moderate (8.9 ± 4.0) depression. In multivariable-adjusted models mild depression was associated with a 12.1-point (95% confidence interval [CI], −17.2 to −6.9) decrease in AFEQT and 1.9-point (95% CI, 1.1 to 2.7) increase in GPSS, while moderate depression a 27.7-point (95% CI, −35.5 to −19.8) decrease in AFEQT and 5.5-point (95% CI, 4.2 to 6.8) increase in GPSS, relative to normal range PHQ. Regression analyses confirmed significant correlations between depression and AFEQT and GPPS scores in multivariable-adjusted models. We determined that depression is associated with a step-wise, progressively adverse change in patient-centered outcomes in individuals with AF. Our findings suggest the importance of assessing depression in the evaluation of AF. Subject term list: health services, atrial fibrillation, risk factors •Depression is a frequent comorbid condition in individuals with atrial fibrillation (AF).•Quality of life and psychological stress are relevant to patients' experience of AF.•We identified strong associations between depression and these patient-reported outcomes.•Addressing depression may improve patient-reported outcomes in AF.