Compromised CD4:CD8 ratio recovery in people living with HIV aged over 50 years: an observational study

Objectives Persistent CD4:CD8 ratio inversion ( 900 cells/μL) decreased. The median pre‐ART CD4:CD8 ratio was 0.41 (IQR 0.24–0.63), and recovery (≥ 1) occurred in 274 of 876 patients (31.3%). Pre‐ and post‐ART CD4:CD8 ratios were lower in those aged > 50 years compared with young adults aged 18–3...

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Bibliographic Details
Published in:HIV medicine 2020-02, Vol.21 (2), p.109-118
Main Authors: Francis‐Morris, A, Mackie, NE, Eliahoo, J, Ramzan, F, Fidler, S, Pollock, KM
Format: Article
Language:English
Subjects:
Age
ageing
Algorithms
Antiretroviral agents
Antiretroviral drugs
Antiretroviral therapy
CD4 antigen
CD4:CD8 ratio
CD4 count
CD8 antigen
CD8 count
Data collection
Diagnosis
HIV
Human immunodeficiency virus
Inversion
Observational studies
older people living with HIV
Original Research
primary HIV infection
Recovery
Regression analysis
Risk management
Young adults
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Summary:Objectives Persistent CD4:CD8 ratio inversion ( 900 cells/μL) decreased. The median pre‐ART CD4:CD8 ratio was 0.41 (IQR 0.24–0.63), and recovery (≥ 1) occurred in 274 of 876 patients (31.3%). Pre‐ and post‐ART CD4:CD8 ratios were lower in those aged > 50 years compared with young adults aged 18–30 years (P 
ISSN:1464-2662
1468-1293
DOI:10.1111/hiv.12800