ATP6L promotes metastasis of colorectal cancer by inducing epithelial‐mesenchymal transition

ATP6L, the C subunit of the V‐ATPase V0 domain, is involved in regulating the acidic tumor micro‐environment and may promote tumor progression. However, the expression and functional role of ATP6L in tumors have not yet been well explored. In this study, we found that ATP6L protein overexpression wa...

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Bibliographic Details
Published in:Cancer science 2020-02, Vol.111 (2), p.477-488
Main Authors: Wang, Jingyi, Chen, Dandan, Song, Wangzhao, Liu, Zhiyong, Ma, Wenjuan, Li, Xiaofeng, Zhang, Chao, Wang, Xin, Wang, Yalei, Yang, Ye, Cao, Wenfeng, Qi, Lisha
Format: Article
Language:English
Subjects:
Adenosine triphosphatase
Angiogenesis
Animals
Antigens, CD - metabolism
Apoptosis
ATP6L
Cadherins - metabolism
Cancer
Cancer therapies
Cell growth
Cell Movement
Chemotherapy
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - metabolism
Colorectal Neoplasms - pathology
Cytology
Epithelial-Mesenchymal Transition
Female
HCT116 Cells
HT29 Cells
Humans
Immunoglobulins
Liver Neoplasms - metabolism
Liver Neoplasms - pathology
Liver Neoplasms - secondary
Male
Medical prognosis
Mesenchyme
Metastases
Metastasis
Mice
Microscopy
Neoplasm Transplantation
Original
Pancreatic cancer
Prognosis
Tumors
Vacuolar Proton-Translocating ATPases - metabolism
Vimentin
Vimentin - metabolism
Xenografts
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Summary:ATP6L, the C subunit of the V‐ATPase V0 domain, is involved in regulating the acidic tumor micro‐environment and may promote tumor progression. However, the expression and functional role of ATP6L in tumors have not yet been well explored. In this study, we found that ATP6L protein overexpression was related to colorectal cancer histological differentiation (P 
ISSN:1347-9032
1349-7006
DOI:10.1111/cas.14283