Erythroferrone lowers hepcidin by sequestering BMP2/6 heterodimer from binding to the BMP type I receptor ALK3

The authors dissect the transcriptional regulatory pathway by which the iron regulatory hormone hepcidin is suppressed by erythroferrone in response to erythropoietin.

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Bibliographic Details
Published in:Blood 2020-02, Vol.135 (6), p.453-456
Main Authors: Wang, Chia-Yu, Xu, Yang, Traeger, Lisa, Dogan, Deniz Y., Xiao, Xia, Steinbicker, Andrea U., Babitt, Jodie L.
Format: Article
Language:English
Subjects:
Animals
Bone Morphogenetic Protein 2 - metabolism
Bone Morphogenetic Protein 6 - metabolism
Bone Morphogenetic Protein Receptors, Type I - metabolism
Cells, Cultured
Cytokines - metabolism
HEK293 Cells
Hepatocytes - metabolism
Hepcidins - metabolism
Humans
Letter to
Mice
Mice, Inbred C57BL
Muscle Proteins - metabolism
Protein Multimerization
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Description
Summary:The authors dissect the transcriptional regulatory pathway by which the iron regulatory hormone hepcidin is suppressed by erythroferrone in response to erythropoietin.
ISSN:0006-4971
1528-0020
1528-0020
DOI:10.1182/blood.2019002620