Endovascular procedures cause transient endothelial injury but do not disrupt mature neointima in Drug Eluting Stents

Extensive application of coronary intravascular procedures has led to the increased need of understanding the injury inflicted to the coronary arterial wall. We aimed to investigate acute and prolonged coronary endothelial injury as a result of guidewire use, repeated intravascular imaging and stent...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2020-02, Vol.10 (1), p.2173-2173, Article 2173
Main Authors: Autar, Anouchska, Taha, Aladdin, van Duin, Richard, Krabbendam-Peters, Ilona, Duncker, Dirk J., Zijlstra, Felix, van Beusekom, Heleen M. M.
Format: Article
Language:English
Subjects:
692/4019/2776
692/4019/592
Animals
Cardiovascular system
Coronary Vessels - injuries
Denudation
Drug delivery
Drug-Eluting Stents - adverse effects
Endothelial cells
Endothelium
Humanities and Social Sciences
Implants
Light microscopy
Microscopy
multidisciplinary
Neointima - diagnostic imaging
Neointima - pathology
Percutaneous Coronary Intervention - adverse effects
Percutaneous Coronary Intervention - instrumentation
Percutaneous Coronary Intervention - methods
Permeability
Postoperative Complications - etiology
Postoperative Complications - pathology
Scanning electron microscopy
Science
Science (multidisciplinary)
Stents
Swine
Tomography, Optical Coherence - adverse effects
Tomography, Optical Coherence - methods
Ultrasonography, Interventional - adverse effects
Ultrasonography, Interventional - methods
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Extensive application of coronary intravascular procedures has led to the increased need of understanding the injury inflicted to the coronary arterial wall. We aimed to investigate acute and prolonged coronary endothelial injury as a result of guidewire use, repeated intravascular imaging and stenting. These interventions were performed in swine (N = 37) and injury was assessed per coronary segment (n = 81) using an Evans Blue dye-exclusion-test. Scanning electron microscopy and light microscopy were then used to visualize the extent and nature of acute (
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-58938-z