Serine–glycine-one-carbon metabolism: vulnerabilities in MYCN-amplified neuroblastoma

In a recent study published in Cancer Research , Xia and colleagues reported that, in cancer, constituents in serine–glycine-one-carbon (SGOC) metabolism exhibit enhanced transcriptional activation and are increasingly utilised, which results in more glucose-derived carbon to serine–glycine biosynth...

Full description

Saved in:
Bibliographic Details
Published in:Oncogenesis (New York, NY) NY), 2020-02, Vol.9 (2), p.14-14, Article 14
Main Authors: Zhao, Erhu, Hou, Jianbing, Cui, Hongjuan
Format: Article
Language:English
Subjects:
13/95
45/41
631/67/2327
631/80/86
Apoptosis
Carbon
Cell Biology
Glycine
Human Genetics
Internal Medicine
Medicine
Medicine & Public Health
Metabolism
Neuroblastoma
Oncology
Review
Review Article
Serine
Transcription activation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In a recent study published in Cancer Research , Xia and colleagues reported that, in cancer, constituents in serine–glycine-one-carbon (SGOC) metabolism exhibit enhanced transcriptional activation and are increasingly utilised, which results in more glucose-derived carbon to serine–glycine biosynthesis. The current work identifies an MYCN-dependent metabolic vulnerability and shows a variety of associations between metabolic reprogramming and enhanced sensitivity to metabolic stress, which may lead the way to unlocking new anticancer therapies. Here, we summarised new insights into the role of SGOC metabolism in the progression of neuroblastoma (NB) with highly activated SGOC metabolism.
ISSN:2157-9024
2157-9024
DOI:10.1038/s41389-020-0200-9