Musa balbisiana Fruit Rich in Polyphenols Attenuates Isoproterenol-Induced Cardiac Hypertrophy in Rats via Inhibition of Inflammation and Oxidative Stress

Musa balbisiana Colla (Family: Musaceae), commonly known as banana and native to India and other parts of Asia, is very rich in nutritional value and has strong antioxidant potential. In the present study, we have developed Musa balbisiana (MB) fruit pulp powder and evaluated its cardioprotective ef...

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Published in:Oxidative medicine and cellular longevity 2020, Vol.2020 (2020), p.1-14
Main Authors: Kumar, Yashwant, Devi, Rajlakshmi, Banerjee, Sanjay K., Kumar, Roshan, Sarma, Partha Pratim, Arava, S., Paramesha, Bugga, Nizami, Hina L., Elancheran, R., Katare, Parmeshwar B., Kumari, Sima, Mahajan, Dinesh
Format: Article
Language:English
Subjects:
Acids
Animals
Cardiac glycosides
Cardiotonic agents
Cardiovascular disease
Chronic illnesses
Diabetes
Fruits
Gene expression
Heart
Heart enlargement
Heart failure
High performance liquid chromatography
Homogenization
Inflammation
Metabolites
Natural products
Oxidative stress
Polyphenols
Retention
Rodents
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Summary:Musa balbisiana Colla (Family: Musaceae), commonly known as banana and native to India and other parts of Asia, is very rich in nutritional value and has strong antioxidant potential. In the present study, we have developed Musa balbisiana (MB) fruit pulp powder and evaluated its cardioprotective effect in cardiac hypertrophy, which is often associated with inflammation and oxidative stress. An ultra-high-pressure liquid chromatography-mass spectrometer (UPLC-MS/MS) has been used for the detection and systematic characterization of the phenolic compounds present in Musa balbisiana fruit pulp. The cardioprotective effect of MB was evaluated in a rat model of isoproterenol- (ISO-) induced cardiac hypertrophy by subcutaneous administration of isoproterenol (5 mg/kg-1/day-1), delivered through an alzet minipump for 14 days. Oral administration of MB fruit pulp powder (200 mg/kg/day) significantly (p
ISSN:1942-0900
1942-0994
DOI:10.1155/2020/7147498