Anti-leucine-rich Glioma Inactivated-1 Encephalitis Associated with Essential Thrombocythemia

Anti-leucine-rich glioma inactivated-1 (anti-LGI1) encephalitis is a subgroup of autoimmune encephalitis. We herein report the case of a 60-year-old man who presented with typical symptoms, including short-term memory loss, mental abnormalities, hyponatremia and seizures characterized by faciobrachi...

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Bibliographic Details
Published in:Internal Medicine 2020/01/15, Vol.59(2), pp.271-275
Main Authors: Yuan, Xiaoling, Man, Xiaoyan, Zhang, Jinbiao, Sun, Jijun, Liang, Jianhua, Ma, Hongling, Tao, Shuxin, Guo, Dong, Liu, Lifeng
Format: Article
Language:English
Subjects:
Adrenal Cortex Hormones - therapeutic use
anti-leucine-rich glioma inactivated-1 encephalitis
Autoantibodies - immunology
Autoimmune diseases
Case Report
Coexistence
Corticosteroids
Encephalitis
Encephalitis - complications
Encephalitis - drug therapy
essential thrombocythemia
faciobrachial dystonic seizures
Glioma
Glioma - complications
Hashimoto Disease - complications
Hashimoto Disease - drug therapy
Humans
Hydroxyurea
Hyponatremia
Hyponatremia - etiology
Internal medicine
Intracellular Signaling Peptides and Proteins - antagonists & inhibitors
Leucine
LGI1 protein
Limbic Encephalitis - complications
Limbic Encephalitis - drug therapy
Male
Middle Aged
Mycophenolate mofetil
Mycophenolic acid
myeloproliferative neoplasms
paraneoplastic syndrome
Seizures
Seizures - etiology
Short term memory
Thrombocythemia, Essential - complications
Thrombocythemia, Essential - drug therapy
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Summary:Anti-leucine-rich glioma inactivated-1 (anti-LGI1) encephalitis is a subgroup of autoimmune encephalitis. We herein report the case of a 60-year-old man who presented with typical symptoms, including short-term memory loss, mental abnormalities, hyponatremia and seizures characterized by faciobrachial dystonic seizures and who was diagnosed with anti-LGI1 encephalitis. At the same time, he was diagnosed with essential thrombocythemia. A significant improvement was obtained by treatment with corticosteroid, immunoglobulin, mycophenolate mofetil, and hydroxyurea. Autoimmune diseases are associated with a significantly increased risk of developing myeloproliferative neoplasms, which may explain the coexistence of anti-LGI1 encephalitis and essential thrombocythema in this patient; however, but more cases and studies are needed to determine whether there is any correlation between these conditions.
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.2963-19