A Radical Approach to Acute Lymphoblastic Leukemia Treatment: A Case Study of a Veterinarian Specializing in Livestock who Developed Disseminated Mucormycosis during Induction Therapy

Mucormycosis has emerged as the third-most common fungal mycosis and is one of the most fatal molds. We herein report a case study of a 30-year-old woman who was a veterinarian, specializing in livestock, who developed disseminated mucormycosis during induction therapy for acute lymphoblastic leukem...

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Bibliographic Details
Published in:Internal Medicine 2020/01/15, Vol.59(2), pp.261-266
Main Authors: Sakai, Toshiro, Sato, Ken, Kikuchi, Tomoki, Obata, Masahiko, Konuma, Yuichi
Format: Article
Language:English
Subjects:
Acute Disease
Acute lymphoblastic leukemia
Adult
Agricultural Workers' Diseases - drug therapy
Animals
Antifungal agents
Antifungal Agents - therapeutic use
Case Report
Case reports
Case studies
dairy workers
disseminated disease
hematopoietic stem cell transplantation
Hematopoietic Stem Cell Transplantation - methods
Humans
Immunocompromised Host
Induction therapy
Internal medicine
Leukemia
Livestock
Lymphatic leukemia
Male
Mucormycosis
Mucormycosis - drug therapy
Mycosis
Opportunistic Infections - drug therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications
Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy
Remission
Risk factors
Transplantation
Transplantation, Homologous - methods
Treatment Outcome
Veterinarians
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Summary:Mucormycosis has emerged as the third-most common fungal mycosis and is one of the most fatal molds. We herein report a case study of a 30-year-old woman who was a veterinarian, specializing in livestock, who developed disseminated mucormycosis during induction therapy for acute lymphoblastic leukemia. We successfully used a radical approach for treatment, including a surgical procedure and allogeneic transplantation, with continuous administration of antifungal agents. Reports of successful treatments are extremely rare, and our case has had the longest documented remission from disseminated disease. We speculate that our case's occupational environment may represent a risk factor for development of mucormycosis.
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.3314-19