Genotype-independent association between vitamin D deficiency and polycystic ovarian syndrome in Lahore, Pakistan

Both vitamin D deficiency and single nucleotide polymorphisms (SNPs) in the gene encoding the vitamin D receptor (VDR) have been widely reported to associate with susceptibility to polycystic ovarian syndrome (PCOS). A case-control study was conducted to study the influence of vitamin D status and g...

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Bibliographic Details
Published in:Scientific reports 2020-02, Vol.10 (1), p.2290-2290, Article 2290
Main Authors: Lone, Nasira M., Riaz, Saba, Eusaph, Amna Z., Mein, Charles A., Wozniak, Eva L., Xenakis, Theodoros, Wu, Zhenqiang, Younis, Sidra, Jolliffe, David A., Junaid, Kashaf, Martineau, Adrian R.
Format: Article
Language:English
Subjects:
25-Hydroxyvitamin D
25-Hydroxyvitamin D3 1-alpha-Hydroxylase - genetics
45
45/22
45/77
631/208/205
692/499
Adult
Age Factors
Body Mass Index
Case-Control Studies
Female
Genetic diversity
Genetic Predisposition to Disease
Genetics
Genotype
Genotype & phenotype
Hip
Humanities and Social Sciences
Humans
multidisciplinary
Pakistan - epidemiology
Polycystic ovary syndrome
Polycystic Ovary Syndrome - blood
Polycystic Ovary Syndrome - epidemiology
Polycystic Ovary Syndrome - etiology
Polymorphism, Single Nucleotide
Receptors, Calcitriol - genetics
Risk Assessment
Risk Factors
Science
Science (multidisciplinary)
Single-nucleotide polymorphism
Statistical analysis
Vitamin D
Vitamin D - analogs & derivatives
Vitamin D - blood
Vitamin D Deficiency - blood
Vitamin D Deficiency - complications
Vitamin D Deficiency - epidemiology
Vitamin D Deficiency - genetics
Vitamin D receptors
Vitamin D-Binding Protein - genetics
Vitamin D3 24-Hydroxylase - genetics
Vitamin deficiency
Young Adult
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Summary:Both vitamin D deficiency and single nucleotide polymorphisms (SNPs) in the gene encoding the vitamin D receptor (VDR) have been widely reported to associate with susceptibility to polycystic ovarian syndrome (PCOS). A case-control study was conducted to study the influence of vitamin D status and genotpye for 24 SNPs in four genes in the vitamin D pathway (VDR, DBP, CYP27B1, CYP24A1) on PCOS. Statistical analyses were conducted to identify phenotypic and genotypic factors associated with risk of PCOS and to test for interactions between genotype and vitamin D status. PCOS was independently associated with lower age, higher body mass index, lower waist-hip ratio, vitamin D deficiency (serum 25-hydroxyvitamin D concentration
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-59228-4