Association between myopia and peripapillary hyperreflective ovoid mass-like structures in children

We investigated the characteristics of children with peripapillary hyperreflective ovoid mass-like structures (PHOMS) and evaluated the associated risk factors. This cross-sectional study included 132 eyes of 66 children with PHOMS and 92 eyes of 46 children without PHOMS (controls) who were assesse...

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Bibliographic Details
Published in:Scientific reports 2020-02, Vol.10 (1), p.2238-2238, Article 2238
Main Authors: Lyu, In Jeong, Park, Kyung-Ah, Oh, Sei Yeul
Format: Article
Language:English
Subjects:
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Adolescent
Case-Control Studies
Child
Children
Cross-Sectional Studies
Female
Health risk assessment
Humanities and Social Sciences
Humans
Male
multidisciplinary
Myopia
Myopia - physiopathology
Optic Disk - physiopathology
Optic nerve
Optic Nerve Diseases - physiopathology
Retrospective Studies
Risk factors
Science
Science (multidisciplinary)
Young Adult
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Summary:We investigated the characteristics of children with peripapillary hyperreflective ovoid mass-like structures (PHOMS) and evaluated the associated risk factors. This cross-sectional study included 132 eyes of 66 children with PHOMS and 92 eyes of 46 children without PHOMS (controls) who were assessed by disc enhanced-depth image spectral-domain (SD) optical coherence tomography (OCT). Univariable and multivariable logistic analyses were performed to evaluate risk factors associated with presence of PHOMS. Among the 66 children with PHOMS, 53 (80.3%) had bilateral and 13 (19.7%) had unilateral PHOMS. The mean age of the PHOMS group was 11.7 ± 2.6 years, and that of the control group was 11.4 ± 3.1 years. The mean spherical equivalent (SE) as determined by cycloplegic refraction was −3.13 ± 1.87 diopters (D) in the PHOMS group and −0.95 ± 2.65 D in the control group. Additionally, mean astigmatism was 0.67 ± 0.89 D and 0.88 ± 1.02 D in the PHOMS group and the control group, respectively. Mean disc size was 1,735 ± 153 µm in the PHOMS group and 1,741 ± 190 µm in the control group, while mean optic nerve head (ONH) tilt angle was 9.84 ± 5.38 degrees in the PHOMS group and 3.71 ± 4.41 degrees in the control group. SE and ONH tilt angle were significantly associated with PHOMS according to both univariable [odds ratio (OR): 1.59; p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-58829-3