Iron-Catalyzed Borrowing Hydrogen β‑C(sp3)‑Methylation of Alcohols

Herein we report the iron-catalyzed β-C(sp3)-methylation of primary alcohols using methanol as a C1 building block. This borrowing hydrogen approach employs a well-defined bench-stable (cyclopentadienone)­iron(0) carbonyl complex as precatalyst (5 mol %) and enables a diverse selection of substitute...

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Bibliographic Details
Published in:ACS catalysis 2019-09, Vol.9 (9), p.8575-8580
Main Authors: Polidano, Kurt, Williams, Jonathan M. J, Morrill, Louis C
Format: Article
Language:English
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Letter
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Summary:Herein we report the iron-catalyzed β-C(sp3)-methylation of primary alcohols using methanol as a C1 building block. This borrowing hydrogen approach employs a well-defined bench-stable (cyclopentadienone)­iron(0) carbonyl complex as precatalyst (5 mol %) and enables a diverse selection of substituted 2-arylethanols to undergo β-C(sp3)-methylation in good isolated yields (24 examples, 65% average yield).
ISSN:2155-5435
2155-5435
DOI:10.1021/acscatal.9b02461