The role of the histamine H4 receptor in atopic dermatitis and psoriasis

Atopic dermatitis (AD) and psoriasis are common skin diseases with a high negative impact on patients' quality of life. Both diseases are mediated by a pro‐inflammatory infiltrate consisting of several cell types, such as T‐cells, antigen‐presenting cells and granulocytes and display disturbed...

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Published in:British journal of pharmacology 2020-02, Vol.177 (3), p.490-502
Main Authors: Schaper‐Gerhardt, Katrin, Rossbach, Kristine, Nikolouli, Eirini, Werfel, Thomas, Gutzmer, Ralf, Mommert, Susanne
Format: Article
Language:English
Subjects:
Animal models
Antigen-presenting cells
Atopic dermatitis
Cell culture
Clinical trials
Dermatitis
Eczema
Histamine
Histamine H1 receptors
Histamine H2 receptors
Inflammation
Leukocytes (granulocytic)
Psoriasis
Quality of life
Review
Skin diseases
Themed Section: Review
Therapeutic applications
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container_issue 3
container_start_page 490
container_title British journal of pharmacology
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creator Schaper‐Gerhardt, Katrin
Rossbach, Kristine
Nikolouli, Eirini
Werfel, Thomas
Gutzmer, Ralf
Mommert, Susanne
description Atopic dermatitis (AD) and psoriasis are common skin diseases with a high negative impact on patients' quality of life. Both diseases are mediated by a pro‐inflammatory infiltrate consisting of several cell types, such as T‐cells, antigen‐presenting cells and granulocytes and display disturbed keratinocyte differentiation. Given the fact that histamine levels are also highly elevated in inflamed skin, it is likely that histamine plays a relevant role in disease pathology. However, antagonists blocking histamine H1 receptor or H2 receptors are largely ineffective in reducing chronic symptoms in AD and psoriasis. Over the last years, much research has been undertaken to shed light into the mode of action of the most recently discovered histamine H4 receptor. This research has shown that H4 receptor antagonists display antipruritic and anti‐inflammatory effects not only in mouse models but also in first human clinical trials, and therefore, H4 receptors might present a novel therapeutic target. In this review, we summarize the effects of the H4 receptors on different cell types, mouse models and clinical studies in regard to AD and psoriasis respectively. Linked Articles This article is part of a themed section on New Uses for 21st Century. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.3/issuetoc
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subjects Animal models
Antigen-presenting cells
Atopic dermatitis
Cell culture
Clinical trials
Dermatitis
Eczema
Histamine
Histamine H1 receptors
Histamine H2 receptors
Inflammation
Leukocytes (granulocytic)
Psoriasis
Quality of life
Review
Skin diseases
Themed Section: Review
Therapeutic applications
title The role of the histamine H4 receptor in atopic dermatitis and psoriasis
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