The Groucho/Transducin‐like enhancer of split protein family in animal development

Corepressors are proteins that cannot bind DNA directly but repress transcription by interacting with partner proteins. The Groucho/Transducin‐Like Enhancer of Split (TLE) are a conserved family of corepressor proteins present in animals ranging from invertebrates such as Drosophila to vertebrates s...

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Published in:IUBMB life 2015-07, Vol.67 (7), p.472-481
Main Authors: Agarwal, Megha, Kumar, Pankaj, Mathew, Sam J.
Format: Article
Language:English
Subjects:
Adipogenesis
Animals
Basic Helix-Loop-Helix Transcription Factors - genetics
Basic Helix-Loop-Helix Transcription Factors - metabolism
Co-Repressor Proteins - genetics
Co-Repressor Proteins - metabolism
corepressor
development
Gene Expression Regulation, Developmental
groucho
Heart - growth & development
Hematopoiesis
homeobox genes
Humans
Kidney - growth & development
Multigene Family
Neurogenesis
Osteogenesis
Pancreas - growth & development
Repressor Proteins - genetics
Repressor Proteins - metabolism
transcription factor
transducin‐like enhancer of split (TLE)
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Summary:Corepressors are proteins that cannot bind DNA directly but repress transcription by interacting with partner proteins. The Groucho/Transducin‐Like Enhancer of Split (TLE) are a conserved family of corepressor proteins present in animals ranging from invertebrates such as Drosophila to vertebrates such as mice and humans. Groucho/TLE proteins perform important functions throughout the life span of animals, interacting with several pathways and regulating fundamental processes such as metabolism. However, these proteins have especially crucial functions in animal development, where they are required in multiple tissues in a temporally regulated manner. In this review, we summarize the functions of the Groucho/TLE proteins during animal development, emphasizing on specific tissues where they play essential roles. © 2015 IUBMB Life, 67(7):472–481, 2015
ISSN:1521-6543
1521-6551
DOI:10.1002/iub.1395