The Composition of Surgical Wound Fluids from Breast Cancer Patients is Affected by Intraoperative Radiotherapy Treatment and Depends on the Molecular Subtype of Breast Cancer

Invasive oncological procedures affect the remaining tumor cells by increasing their survival, proliferation, and migration through the induction of wound healing response. The phenomena of local relapse after breast-conserving surgery (BCS) has resulted in a series of research and clinical trials w...

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Bibliographic Details
Published in:Cancers 2019-12, Vol.12 (1), p.11
Main Authors: Kulcenty, Katarzyna, Piotrowski, Igor, Wróblewska, Joanna Patrycja, Wasiewicz, Janusz, Suchorska, And Wiktoria Maria
Format: Article
Language:English
Subjects:
Angiogenesis
Breast cancer
Cancer surgery
Cancer therapies
Cell proliferation
Clinical trials
Cytokines
Epidermal growth factor
Genotype & phenotype
Immune response
Invasiveness
Metastasis
Microenvironments
Patients
Radiation therapy
Stem cells
Surgery
Tumor cells
Tumors
Wound healing
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Summary:Invasive oncological procedures affect the remaining tumor cells by increasing their survival, proliferation, and migration through the induction of wound healing response. The phenomena of local relapse after breast-conserving surgery (BCS) has resulted in a series of research and clinical trials with the aim of assessing whether localized intraoperative radiotherapy (IORT), may be beneficial in inhibiting local recurrences. Therefore, it is essential to assess the impact of intraoperative radiotherapy in modulating the immunological response and wound healing process. Thus, we decided to perform a quantitative analysis of the composition of surgical wound fluids (SWF) in two groups of breast cancer (BC) patients: those treated with BCS followed by IORT, and those who underwent BCS alone. We found that several cytokines, which are believed to have anti-tumor properties, were highly expressed in the luminal A breast cancer subtype in the IORT treatment group. Interestingly, we also found significant differences between IORT patients with tumors of different molecular subtypes. Based on these findings, we hypothesized that IORT treatment might be beneficial in changing the tumor bed microenvironment, making it less favorable for tumor recurrence due to decreased concentration of tumor-facilitating cytokines, especially in the luminal A subtype of BC.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers12010011