Cannabinoids as an alternative option for conventional analgesics in cancer pain management: A pharmacogenomics perspective

The global cancer burden is significantly increasing at an alarming rate affecting patients, relatives, communities, and health-care system. Cancer patients require adequate pain relief and palliative care throughout the life course, especially in terminal illness. Although opioid treatment is succe...

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Bibliographic Details
Published in:Indian journal of palliative care 2020-01, Vol.26 (1), p.129-133
Main Authors: Jose, Anmi, Thomas, Levin, Baburaj, Gayathri, Munisamy, Murali, Rao, Mahadev
Format: Article
Language:English
Subjects:
Analgesia
Analgesics
Cancer pain
Cancer patients
Cancer therapies
Cannabidiol
Cannabinoids
Chemotherapy
Cytochrome
Diseases
Drug dosages
Enzymes
Health
Lung cancer
Lymphoma
Marijuana
Medical marijuana
Metabolism
Nabilone
Narcotics
Nausea
Nonsteroidal anti-inflammatory drugs
Opioids
Pain management
Palliative care
Patients
Pharmacogenomics
Phenols (Class of compounds)
Review
Skin cancer
Thyroid gland
Toxicity
Vomiting
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Summary:The global cancer burden is significantly increasing at an alarming rate affecting patients, relatives, communities, and health-care system. Cancer patients require adequate pain relief and palliative care throughout the life course, especially in terminal illness. Although opioid treatment is successful in majority of patients, around 40% do not achieve enough analgesia or are prone to serious side effects and toxicity. The treatment of medical conditions with cannabis and cannabinoid compounds is constantly expanding. This review organizes the current knowledge in the context of SNPs associated with opioids and nonopioids and its clinical consequences in pain management and pharmacogenetic targets of cannabinoids, for use in clinical practice.
ISSN:0973-1075
1998-3735
DOI:10.4103/IJPC.IJPC_155_19