An evaluation of rivaroxaban and clopidogrel in a rat lower extremity ischemia-reperfusion model: An experimental study

This study aims to compare clopidogrel and rivaroxaban against ischemia-reperfusion injury after a long reperfusion time and to investigate its effects on various tissues. A total of 40 Wistar rats were included in the study and were randomly divided into four groups (n=10 per group). Groups were de...

Full description

Saved in:
Bibliographic Details
Published in:Türk göğüs kalp damar cerrahisi dergisi 2019-10, Vol.27 (4), p.513-520
Main Authors: Özbudak, Ersan, Eraldemir, Fatma Ceyla, Arıkan, Ali Ahmet, Şahin, Deniz, Maral Kır, Hale, Kurt, Tolga, Gülaştı, Ömer Faruk, Yavuz, Şadan
Format: Article
Language:English
Subjects:
Original
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c420t-43fdbf4f8b062e5e1ee32a19cc8e47c86101da0b868e39b4a5cf00e0e2d8dabd3
cites
container_end_page 520
container_issue 4
container_start_page 513
container_title Türk göğüs kalp damar cerrahisi dergisi
container_volume 27
creator Özbudak, Ersan
Eraldemir, Fatma Ceyla
Arıkan, Ali Ahmet
Şahin, Deniz
Maral Kır, Hale
Kurt, Tolga
Gülaştı, Ömer Faruk
Yavuz, Şadan
description This study aims to compare clopidogrel and rivaroxaban against ischemia-reperfusion injury after a long reperfusion time and to investigate its effects on various tissues. A total of 40 Wistar rats were included in the study and were randomly divided into four groups (n=10 per group). Groups were defined as follows: control (Group 1), sham (Group 2), clopidogrel pre-treatment (Group 3), and rivaroxaban pre-treatment (Group 4). Ischemia (6 h) and reperfusion (8 h) were induced at the lower hind limb in Groups 2, 3, and 4. The ischemic muscle, heart, kidney, liver, and plasma tissues of the subjects were obtained to test for the oxidant (malondialdehyde) and antioxidants (glutathione, superoxide dismutase, and nitric oxide). Malondialdehyde levels were significantly higher in the sham group, compared to the controls in all tissues. Clopidogrel and rivaroxaban pre-treatment significantly decreased malondialdehyde levels, compared to the heart, ischemic muscle, liver, and blood tissues of the sham group. Kidney malondialdehyde levels were reduced only by rivaroxaban. Group 4 had significantly decreased malondialdehyde levels, compared to Group 3 in ischemic muscle (p
doi_str_mv 10.5606/tgkdc.dergisi.2019.18061
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7018153</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2362076732</sourcerecordid><originalsourceid>FETCH-LOGICAL-c420t-43fdbf4f8b062e5e1ee32a19cc8e47c86101da0b868e39b4a5cf00e0e2d8dabd3</originalsourceid><addsrcrecordid>eNpVkVFvFCEQx4nR2EvtVzA8-rLnALsc64NJ01g1aeKLPhMWZq8ou5zAXu--vVx7NsrLkGHmP3_mRwhlsO4kyPdl-8vZtcO09dmvObB-zRRI9oKsOGv7RrFOviQrJoA1nVRwQa5y_gn1SCZa1b0mF4KD4j3rV-Theqa4N2ExxceZxpEmvzcpHsxgZmpmR22IO-_iNmGgvqZoMoWG-ICJ4qEknHw5Up_tfb2ZJuEO07jkk9gUHYYP9DThULN-wrmYQHNZ3PENeTWakPHqHC_Jj9tP32--NHffPn-9ub5rbMuhNK0Y3TC2oxpAcuyQIQpuWG-twnZjlWTAnIFBSYWiH1rT2REAAblTzgxOXJKPT7q7ZZjQ2WohmaB31Y1JRx2N1_-_zP5eb-Neb4DVRYoq8O4skOLvBXPRU_0shmBmjEvWXEgOG7kRvJaqp1KbYs4Jx-cxDPQJnX5Ep8_o9AmdfkRXW9_-a_O58S8o8QdKvZ3D</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2362076732</pqid></control><display><type>article</type><title>An evaluation of rivaroxaban and clopidogrel in a rat lower extremity ischemia-reperfusion model: An experimental study</title><source>PubMed Central</source><creator>Özbudak, Ersan ; Eraldemir, Fatma Ceyla ; Arıkan, Ali Ahmet ; Şahin, Deniz ; Maral Kır, Hale ; Kurt, Tolga ; Gülaştı, Ömer Faruk ; Yavuz, Şadan</creator><creatorcontrib>Özbudak, Ersan ; Eraldemir, Fatma Ceyla ; Arıkan, Ali Ahmet ; Şahin, Deniz ; Maral Kır, Hale ; Kurt, Tolga ; Gülaştı, Ömer Faruk ; Yavuz, Şadan</creatorcontrib><description>This study aims to compare clopidogrel and rivaroxaban against ischemia-reperfusion injury after a long reperfusion time and to investigate its effects on various tissues. A total of 40 Wistar rats were included in the study and were randomly divided into four groups (n=10 per group). Groups were defined as follows: control (Group 1), sham (Group 2), clopidogrel pre-treatment (Group 3), and rivaroxaban pre-treatment (Group 4). Ischemia (6 h) and reperfusion (8 h) were induced at the lower hind limb in Groups 2, 3, and 4. The ischemic muscle, heart, kidney, liver, and plasma tissues of the subjects were obtained to test for the oxidant (malondialdehyde) and antioxidants (glutathione, superoxide dismutase, and nitric oxide). Malondialdehyde levels were significantly higher in the sham group, compared to the controls in all tissues. Clopidogrel and rivaroxaban pre-treatment significantly decreased malondialdehyde levels, compared to the heart, ischemic muscle, liver, and blood tissues of the sham group. Kidney malondialdehyde levels were reduced only by rivaroxaban. Group 4 had significantly decreased malondialdehyde levels, compared to Group 3 in ischemic muscle (p&lt;0.010). The glutathione reduction, compared to sham group, in the kidney was only significant for Group 4 (p&lt;0.050). With clopidogrel and rivaroxaban pretreatment, nitric oxide levels significantly decreased only in the heart tissue, compared to sham group (p&lt;0.001 and p&lt;0.050, respectively). The study results suggest that rivaroxaban and clopidogrel are effective in reducing ischemia-reperfusion injury in the heart, ischemic muscle, liver, and blood. Rivaroxaban also protects the kidneys and is superior to clopidogrel in ischemic muscle protection.</description><identifier>ISSN: 1301-5680</identifier><identifier>EISSN: 2149-8156</identifier><identifier>DOI: 10.5606/tgkdc.dergisi.2019.18061</identifier><identifier>PMID: 32082919</identifier><language>eng</language><publisher>Turkey: Bayçınar Medical Publishing</publisher><subject>Original</subject><ispartof>Türk göğüs kalp damar cerrahisi dergisi, 2019-10, Vol.27 (4), p.513-520</ispartof><rights>Copyright © 2019, Turkish Society of Cardiovascular Surgery.</rights><rights>Copyright © 2019, Turkish Society of Cardiovascular Surgery 2019 Turkish Society of Cardiovascular Surgery</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-43fdbf4f8b062e5e1ee32a19cc8e47c86101da0b868e39b4a5cf00e0e2d8dabd3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018153/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018153/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32082919$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Özbudak, Ersan</creatorcontrib><creatorcontrib>Eraldemir, Fatma Ceyla</creatorcontrib><creatorcontrib>Arıkan, Ali Ahmet</creatorcontrib><creatorcontrib>Şahin, Deniz</creatorcontrib><creatorcontrib>Maral Kır, Hale</creatorcontrib><creatorcontrib>Kurt, Tolga</creatorcontrib><creatorcontrib>Gülaştı, Ömer Faruk</creatorcontrib><creatorcontrib>Yavuz, Şadan</creatorcontrib><title>An evaluation of rivaroxaban and clopidogrel in a rat lower extremity ischemia-reperfusion model: An experimental study</title><title>Türk göğüs kalp damar cerrahisi dergisi</title><addtitle>Turk Gogus Kalp Damar Cerrahisi Derg</addtitle><description>This study aims to compare clopidogrel and rivaroxaban against ischemia-reperfusion injury after a long reperfusion time and to investigate its effects on various tissues. A total of 40 Wistar rats were included in the study and were randomly divided into four groups (n=10 per group). Groups were defined as follows: control (Group 1), sham (Group 2), clopidogrel pre-treatment (Group 3), and rivaroxaban pre-treatment (Group 4). Ischemia (6 h) and reperfusion (8 h) were induced at the lower hind limb in Groups 2, 3, and 4. The ischemic muscle, heart, kidney, liver, and plasma tissues of the subjects were obtained to test for the oxidant (malondialdehyde) and antioxidants (glutathione, superoxide dismutase, and nitric oxide). Malondialdehyde levels were significantly higher in the sham group, compared to the controls in all tissues. Clopidogrel and rivaroxaban pre-treatment significantly decreased malondialdehyde levels, compared to the heart, ischemic muscle, liver, and blood tissues of the sham group. Kidney malondialdehyde levels were reduced only by rivaroxaban. Group 4 had significantly decreased malondialdehyde levels, compared to Group 3 in ischemic muscle (p&lt;0.010). The glutathione reduction, compared to sham group, in the kidney was only significant for Group 4 (p&lt;0.050). With clopidogrel and rivaroxaban pretreatment, nitric oxide levels significantly decreased only in the heart tissue, compared to sham group (p&lt;0.001 and p&lt;0.050, respectively). The study results suggest that rivaroxaban and clopidogrel are effective in reducing ischemia-reperfusion injury in the heart, ischemic muscle, liver, and blood. Rivaroxaban also protects the kidneys and is superior to clopidogrel in ischemic muscle protection.</description><subject>Original</subject><issn>1301-5680</issn><issn>2149-8156</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNpVkVFvFCEQx4nR2EvtVzA8-rLnALsc64NJ01g1aeKLPhMWZq8ou5zAXu--vVx7NsrLkGHmP3_mRwhlsO4kyPdl-8vZtcO09dmvObB-zRRI9oKsOGv7RrFOviQrJoA1nVRwQa5y_gn1SCZa1b0mF4KD4j3rV-Theqa4N2ExxceZxpEmvzcpHsxgZmpmR22IO-_iNmGgvqZoMoWG-ICJ4qEknHw5Up_tfb2ZJuEO07jkk9gUHYYP9DThULN-wrmYQHNZ3PENeTWakPHqHC_Jj9tP32--NHffPn-9ub5rbMuhNK0Y3TC2oxpAcuyQIQpuWG-twnZjlWTAnIFBSYWiH1rT2REAAblTzgxOXJKPT7q7ZZjQ2WohmaB31Y1JRx2N1_-_zP5eb-Neb4DVRYoq8O4skOLvBXPRU_0shmBmjEvWXEgOG7kRvJaqp1KbYs4Jx-cxDPQJnX5Ep8_o9AmdfkRXW9_-a_O58S8o8QdKvZ3D</recordid><startdate>20191001</startdate><enddate>20191001</enddate><creator>Özbudak, Ersan</creator><creator>Eraldemir, Fatma Ceyla</creator><creator>Arıkan, Ali Ahmet</creator><creator>Şahin, Deniz</creator><creator>Maral Kır, Hale</creator><creator>Kurt, Tolga</creator><creator>Gülaştı, Ömer Faruk</creator><creator>Yavuz, Şadan</creator><general>Bayçınar Medical Publishing</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20191001</creationdate><title>An evaluation of rivaroxaban and clopidogrel in a rat lower extremity ischemia-reperfusion model: An experimental study</title><author>Özbudak, Ersan ; Eraldemir, Fatma Ceyla ; Arıkan, Ali Ahmet ; Şahin, Deniz ; Maral Kır, Hale ; Kurt, Tolga ; Gülaştı, Ömer Faruk ; Yavuz, Şadan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-43fdbf4f8b062e5e1ee32a19cc8e47c86101da0b868e39b4a5cf00e0e2d8dabd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Original</topic><toplevel>online_resources</toplevel><creatorcontrib>Özbudak, Ersan</creatorcontrib><creatorcontrib>Eraldemir, Fatma Ceyla</creatorcontrib><creatorcontrib>Arıkan, Ali Ahmet</creatorcontrib><creatorcontrib>Şahin, Deniz</creatorcontrib><creatorcontrib>Maral Kır, Hale</creatorcontrib><creatorcontrib>Kurt, Tolga</creatorcontrib><creatorcontrib>Gülaştı, Ömer Faruk</creatorcontrib><creatorcontrib>Yavuz, Şadan</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Türk göğüs kalp damar cerrahisi dergisi</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Özbudak, Ersan</au><au>Eraldemir, Fatma Ceyla</au><au>Arıkan, Ali Ahmet</au><au>Şahin, Deniz</au><au>Maral Kır, Hale</au><au>Kurt, Tolga</au><au>Gülaştı, Ömer Faruk</au><au>Yavuz, Şadan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An evaluation of rivaroxaban and clopidogrel in a rat lower extremity ischemia-reperfusion model: An experimental study</atitle><jtitle>Türk göğüs kalp damar cerrahisi dergisi</jtitle><addtitle>Turk Gogus Kalp Damar Cerrahisi Derg</addtitle><date>2019-10-01</date><risdate>2019</risdate><volume>27</volume><issue>4</issue><spage>513</spage><epage>520</epage><pages>513-520</pages><issn>1301-5680</issn><eissn>2149-8156</eissn><abstract>This study aims to compare clopidogrel and rivaroxaban against ischemia-reperfusion injury after a long reperfusion time and to investigate its effects on various tissues. A total of 40 Wistar rats were included in the study and were randomly divided into four groups (n=10 per group). Groups were defined as follows: control (Group 1), sham (Group 2), clopidogrel pre-treatment (Group 3), and rivaroxaban pre-treatment (Group 4). Ischemia (6 h) and reperfusion (8 h) were induced at the lower hind limb in Groups 2, 3, and 4. The ischemic muscle, heart, kidney, liver, and plasma tissues of the subjects were obtained to test for the oxidant (malondialdehyde) and antioxidants (glutathione, superoxide dismutase, and nitric oxide). Malondialdehyde levels were significantly higher in the sham group, compared to the controls in all tissues. Clopidogrel and rivaroxaban pre-treatment significantly decreased malondialdehyde levels, compared to the heart, ischemic muscle, liver, and blood tissues of the sham group. Kidney malondialdehyde levels were reduced only by rivaroxaban. Group 4 had significantly decreased malondialdehyde levels, compared to Group 3 in ischemic muscle (p&lt;0.010). The glutathione reduction, compared to sham group, in the kidney was only significant for Group 4 (p&lt;0.050). With clopidogrel and rivaroxaban pretreatment, nitric oxide levels significantly decreased only in the heart tissue, compared to sham group (p&lt;0.001 and p&lt;0.050, respectively). The study results suggest that rivaroxaban and clopidogrel are effective in reducing ischemia-reperfusion injury in the heart, ischemic muscle, liver, and blood. Rivaroxaban also protects the kidneys and is superior to clopidogrel in ischemic muscle protection.</abstract><cop>Turkey</cop><pub>Bayçınar Medical Publishing</pub><pmid>32082919</pmid><doi>10.5606/tgkdc.dergisi.2019.18061</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1301-5680
ispartof Türk göğüs kalp damar cerrahisi dergisi, 2019-10, Vol.27 (4), p.513-520
issn 1301-5680
2149-8156
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7018153
source PubMed Central
subjects Original
title An evaluation of rivaroxaban and clopidogrel in a rat lower extremity ischemia-reperfusion model: An experimental study
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T08%3A50%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=An%20evaluation%20of%20rivaroxaban%20and%20clopidogrel%20in%20a%20rat%20lower%20extremity%20ischemia-reperfusion%20model:%20An%20experimental%20study&rft.jtitle=T%C3%BCrk%20g%C3%B6%C4%9F%C3%BCs%20kalp%20damar%20cerrahisi%20dergisi&rft.au=%C3%96zbudak,%20Ersan&rft.date=2019-10-01&rft.volume=27&rft.issue=4&rft.spage=513&rft.epage=520&rft.pages=513-520&rft.issn=1301-5680&rft.eissn=2149-8156&rft_id=info:doi/10.5606/tgkdc.dergisi.2019.18061&rft_dat=%3Cproquest_pubme%3E2362076732%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c420t-43fdbf4f8b062e5e1ee32a19cc8e47c86101da0b868e39b4a5cf00e0e2d8dabd3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2362076732&rft_id=info:pmid/32082919&rfr_iscdi=true