Nonalcoholic Fatty Liver Disease: A Challenge from Mechanisms to Therapy

Focusing on previously published mechanisms of non-alcoholic fatty liver disease (NAFLD), their uncertainty does not always permit a clear elucidation of the grassroot alterations that are at the basis of the wide-spread illness, and thus curing it is still a challenge. There is somehow exceptional...

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Bibliographic Details
Published in:Journal of clinical medicine 2019-12, Vol.9 (1), p.15
Main Authors: Tarantino, Giovanni, Citro, Vincenzo, Capone, Domenico
Format: Article
Language:English
Subjects:
Adaptation
Adipocytes
Apoptosis
Body fat
Clinical medicine
Cytokines
Energy
Hypotheses
Inflammation
Insulin resistance
Liver diseases
Malnutrition
Metabolic syndrome
Nutrition research
Obesity
Oxidative stress
Polymorphism
Review
Thermogenesis
Weight control
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Summary:Focusing on previously published mechanisms of non-alcoholic fatty liver disease (NAFLD), their uncertainty does not always permit a clear elucidation of the grassroot alterations that are at the basis of the wide-spread illness, and thus curing it is still a challenge. There is somehow exceptional progress, but many controversies persist in NAFLD research and clinical investigation. It is likely that hidden mechanisms will be brought to light in the near future. Hereby, the authors present, with some criticism, classical mechanisms that stand at the basis of NAFLD, and consider contextually different emerging processes. Without ascertaining these complex interactions, investigators have a long way left ahead before finding an effective therapy for NAFLD beyond diet and exercise.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm9010015