Preoperative Ascorbic Acid Levels in Proximal Femur Fracture Patients Have No Postoperative Clinical Impact, While Ascorbic Acid Levels upon Discharge Have a Major Effect on Postoperative Outcome

Proximal femur fractures show a high prevalence in elderly patients and are associated with an elevated risk of multimorbidity and early mortality. Recovery is impaired by malnutrition and oxidative stress, which is affected by antioxidants such as ascorbic acid (AA). This study monitored AA levels...

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Bibliographic Details
Published in:Journal of clinical medicine 2019-12, Vol.9 (1), p.66
Main Authors: Hill-Mündel, Katharina, Schlegl, Johannes, Biesalski, Hans Konrad, Ehnert, Sabrina, Schröter, Steffen, Bahrs, Christian, Nohr, Donatus, Nüssler, Andreas K, Ihle, Christoph
Format: Article
Language:English
Subjects:
Acids
Clinical medicine
Food
Food supply
Fractures
Geriatrics
Interviews
Malnutrition
Mortality
Nutritional status
Older people
Orthopedics
Oxidative stress
Patients
Plasma
Software
Surgery
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Summary:Proximal femur fractures show a high prevalence in elderly patients and are associated with an elevated risk of multimorbidity and early mortality. Recovery is impaired by malnutrition and oxidative stress, which is affected by antioxidants such as ascorbic acid (AA). This study monitored AA levels during hospitalization of patients with a proximal femur to investigate the influence of AA status to the clinical outcome. AA levels of 25 elderly patients with a proximal femur fracture were measured during hospitalization using high performance liquid chromatography. Plasma samples were collected preoperatively, on the first day after surgery, on the third day after surgery and on the day of discharge. Nutritional Risk Screening 2002 (NRS) and Mini Nutritional Assessment (MNA) were assessed to evaluate the nutritional status. In patients with proximal femoral fractures, preoperative AA concentrations were significantly lower compared to elderly patients without an acute fracture. A significant decrease of 33.8% in AA plasma level was measured on the day after surgery with a significant recovery up to the time of discharge. The preoperative AA status did not have any significant effect on clinical outcome. However, inadequate AA levels (
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm9010066