Is Polymicrobial Bacteremia an Independent Risk Factor for Mortality in Acinetobacter baumannii Bacteremia?

This retrospective observational study assessed the differences between monomicrobial and polymicrobial bacteremia and identified possible independent risk factors for 14-day mortality. There were 379 patients with bacteremia admitted to a tertiary care center in northern Taiwan between August 2008...

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Bibliographic Details
Published in:Journal of clinical medicine 2020-01, Vol.9 (1), p.153
Main Authors: Wang, Yung-Chih, Ku, Wen-Wei, Yang, Ya-Sung, Kao, Chih-Chun, Kang, Fang-Yu, Kuo, Shu-Chen, Chiu, Chun-Hsiang, Chen, Te-Li, Wang, Fu-Der, Lee, And Yi-Tzu
Format: Article
Language:English
Subjects:
Antimicrobial agents
Cardiovascular disease
Clinical medicine
Infections
Medical records
Microorganisms
Mortality
Pathogens
Risk factors
Survival analysis
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Summary:This retrospective observational study assessed the differences between monomicrobial and polymicrobial bacteremia and identified possible independent risk factors for 14-day mortality. There were 379 patients with bacteremia admitted to a tertiary care center in northern Taiwan between August 2008 and July 2015 enrolled for data analysis. Among them, 89 patients (23.5%) had polymicrobial bacteremia and 290 patients (76.5%) had monomicrobial bacteremia. No significant difference in 14-day mortality was observed between patients with monomicrobial and polymicrobial bacteremia (26.9% vs. 29.2%, = 0.77). Logistic regression controlled for confounders demonstrated that polymicrobial bacteremia was not an independent predictor of mortality, whereas appropriate antimicrobial therapy was independently associated with reduced mortality. Higher 14-day mortality rates were observed in the polymicrobial bacteremic patients with concomitant isolation of , , and spp. from the bloodstream. Compared with patients with monomicrobial multidrug-resistant (MDRAb) bacteremia, those with MDRAb concomitant with Gram-negative bacilli bacteremia had a worse outcome. Polymicrobial bacteremia was not associated with a higher 14-day mortality rate than that of monomicrobial bacteremia, although more deaths were observed when certain Gram-negative bacteria were concomitantly isolated. Appropriate antimicrobial therapy remains an important life-saving measure for bacteremic patients.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm9010153