Tumor Angiogenesis and Anti-Angiogenic Strategies for Cancer Treatment

Angiogenesis is the process through which novel blood vessels are formed from pre-existing ones and it is involved in both physiological and pathological processes of the body. Furthermore, tumor angiogenesis is a crucial factor associated with tumor growth, progression, and metastasis. In this mann...

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Bibliographic Details
Published in:Journal of clinical medicine 2019-12, Vol.9 (1), p.84
Main Authors: Teleanu, Raluca Ioana, Chircov, Cristina, Grumezescu, Alexandru Mihai, Teleanu, Daniel Mihai
Format: Article
Language:English
Subjects:
Angiogenesis
Blood platelets
Blood vessels
Cardiovascular system
Clinical medicine
Heparan sulfate
Homeostasis
Hypoxia
Kinases
Physiology
Proteins
Review
Tumor necrosis factor-TNF
Vascular endothelial growth factor
Wound healing
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Summary:Angiogenesis is the process through which novel blood vessels are formed from pre-existing ones and it is involved in both physiological and pathological processes of the body. Furthermore, tumor angiogenesis is a crucial factor associated with tumor growth, progression, and metastasis. In this manner, there has been a great interest in the development of anti-angiogenesis strategies that could inhibit tumor vascularization. Conventional approaches comprise the administration of anti-angiogenic drugs that target and block the activity of proangiogenic factors. However, as their efficacy is still a matter of debate, novel strategies have been focusing on combining anti-angiogenic agents with chemotherapy or immunotherapy. Moreover, nanotechnology has also been investigated for the potential of nanomaterials to target and release anti-angiogenic drugs at specific sites. The aim of this paper is to review the mechanisms involved in angiogenesis and tumor vascularization and provide an overview of the recent trends in anti-angiogenic strategies for cancer therapy.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm9010084