Possible Use of Blood Tryptophan Metabolites as Biomarkers for Coronary Heart Disease in Sudden Unexpected Death

Coronary heart disease (CHD) is the major cause of death in sudden unexpected death (SUD) cases. Tryptophan (TRP) and its metabolites are correlated with the CHD patient but less studies in the SUD. The aim of this study was to evaluate the relationship of TRP and its metabolites with the CHD in the...

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Bibliographic Details
Published in:Metabolites 2019-12, Vol.10 (1), p.6
Main Authors: Santisukwongchote, Kobchai, Amornlertwatana, Yutti, Sastraruji, Thanapat, Jaikang, Churdsak
Format: Article
Language:English
Subjects:
Acids
Antioxidants
Atherosclerosis
Autopsy
Biomarkers
Cardiovascular disease
Coronary artery disease
Coronary vessels
Death
Enzymes
Ethnicity
Heart
Heart diseases
High-performance liquid chromatography
Hypertension
Kynurenic acid
Males
Metabolism
Metabolites
Morphology
Occlusion
Oxidative stress
Picolinic acid
Quinolinic acid
Tryptophan
Xanthurenic acid
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Summary:Coronary heart disease (CHD) is the major cause of death in sudden unexpected death (SUD) cases. Tryptophan (TRP) and its metabolites are correlated with the CHD patient but less studies in the SUD. The aim of this study was to evaluate the relationship of TRP and its metabolites with the CHD in the SUD cases. Blood samples and heart tissues were collected from CHD subjects ( = 31) and the control group ( = 72). Levels of kynurenine (KYN), kynurenic acid (KYA), xanthurenic acid (XAN), 3-hydroxyanthranillic acid (HAA), quinolinic acid (QA), picolinic acid (PA) and 5-hydroxyindoleacetic acid (HIAA) were determined by HPLC-DAD. A severity of heart occlusion was categorized into four groups, and the relationship was measured with the TRP metabolites. The HIAA and The KYN levels significantly differed ( < 0.01) between the CHD group and the control group. Lower levels of QA/XAN, PA/KA, HAA/XAN, KYN/XAN and KYN/TRP were found in the CHD group. However, PA/HAA, PA/HIAA, PA/KYN and XAN/KA values in the CHD group were higher than the control group ( < 0.05). This study revealed that the values of PA/KA and PA/HAA provided better choices for a CHD biomarker in postmortem bodies.
ISSN:2218-1989
2218-1989
DOI:10.3390/metabo10010006