Gamma Ray-Induced Polymerization and Cross-Linking for Optimization of PPy/PVP Hydrogel as Biomaterial

Conducting polymer (CP)-based hydrogels exhibit the behaviors of bending or contraction/relaxation due to electrical stimulation. They are similar in some ways to biological organs and have advantages regarding manipulation and miniaturization. Thus, these hydrogels have attracted considerable inter...

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Bibliographic Details
Published in:Polymers 2020-01, Vol.12 (1), p.111
Main Authors: Jeong, Jin-Oh, Park, Jong-Seok, Kim, Young-Ah, Yang, Su-Jin, Jeong, Sung-In, Lee, Jae-Young, Lim, Youn-Mook
Format: Article
Language:English
Subjects:
Aluminum
Biomedical materials
Biopsy
Biosensors
Compressive strength
Conducting polymers
Crosslinking
Cytotoxicity
Fourier transforms
Gamma rays
Hydrogels
Mechanical properties
Miniaturization
Optimization
Organs
Polymerization
Polymers
Radiation
Scanning electron microscopy
Swelling ratio
Tissue engineering
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Summary:Conducting polymer (CP)-based hydrogels exhibit the behaviors of bending or contraction/relaxation due to electrical stimulation. They are similar in some ways to biological organs and have advantages regarding manipulation and miniaturization. Thus, these hydrogels have attracted considerable interest for biomedical applications. In this study, we prepared PPy/PVP hydrogel with different concentrations and content through polymerization and cross-linking induced by gamma-ray irradiation at 25 kGy to optimize the mechanical properties of the resulting PPy/PVP hydrogel. Optimization of the PPy/PVP hydrogel was confirmed by characterization using scanning electron microscopy, gel fraction, swelling ratio, and Fourier transform infrared spectroscopy. In addition, we assessed live-cell viability using live/dead assay and CCK-8 assay, and found good cell viability regardless of the concentration and content of Py/pTS. The conductivity of PPy/PVP hydrogel was at least 13 mS/cm. The mechanical properties of PPy/PVP hydrogel are important factors in their application for biomaterials. It was found that 0.15PPy/PVP20 (51.96 ± 6.12 kPa) exhibited better compressive strength than the other samples for use in CP-based hydrogels. Therefore, it was concluded that gamma rays can be used to optimize PPy/PVP hydrogel and that biomedical applications of CP-based hydrogels will be possible.
ISSN:2073-4360
2073-4360
DOI:10.3390/polym12010111