Transcriptome analysis of ankylosed primary molars with infraocclusion

Primary molar ankylosis with infraocclusion can retard dental arch development and cause dental asymmetry. Despite its widespread prevalence, little is known about its molecular etiology and pathogenesis. To address this, RNA sequencing was used to generate transcriptomes of furcal bone from infraoc...

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Bibliographic Details
Published in:International journal of oral science 2020-02, Vol.12 (1), p.7-7, Article 7
Main Authors: Tong, Annie, Chow, Yuh-Lit, Xu, Katie, Hardiman, Rita, Schneider, Paul, Tan, Seong-Seng
Format: Article
Language:English
Subjects:
692/700/3032/3039/3046
692/700/3032/3128/3046
692/700/3032/3145/3128/3046
692/700/3032/3148
Adolescent
Ankylosis
Cementum
Child
Dental Cementum - pathology
Dental enamel
Dentistry
Epithelial cells
Epithelium
Etiology
Female
Gene expression
Gene Expression Profiling
Humans
Inflammation
Male
Malocclusion - etiology
Malocclusion - genetics
Malocclusion - pathology
Medicine
Molar - pathology
Molars
Oral and Maxillofacial Surgery
Orthopedics
Periodontal Ligament
Principal components analysis
Ribonucleic acid
RNA
Sequence Analysis, RNA
Surgical Orthopedics
Teeth
Tooth Ankylosis - genetics
Tooth Ankylosis - pathology
Tooth Movement Techniques
Tooth, Deciduous - pathology
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Summary:Primary molar ankylosis with infraocclusion can retard dental arch development and cause dental asymmetry. Despite its widespread prevalence, little is known about its molecular etiology and pathogenesis. To address this, RNA sequencing was used to generate transcriptomes of furcal bone from infraoccluded ( n  = 7) and non-infraoccluded ( n  = 9) primary second molars, all without succeeding biscuspids. Of the 18 529 expressed genes, 432 (2.3%) genes were differentially expressed between the two groups (false discovery rate 
ISSN:1674-2818
2049-3169
DOI:10.1038/s41368-019-0070-1