Effect of manual approaches with osteopathic modality on brain correlates of interoception: an fMRI study

The present randomised placebo controlled trial explored the extent to which osteopathic manipulative treatment (OMT) affects brain activity, particularly the insula, during both an “interoceptive awareness” and “exteroceptive awareness” task in a sample of 32 right-handed adults with chronic Low Ba...

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Bibliographic Details
Published in:Scientific reports 2020-02, Vol.10 (1), p.3214-3214, Article 3214
Main Authors: Cerritelli, Francesco, Chiacchiaretta, Piero, Gambi, Francesco, Perrucci, Mauro Gianni, Barassi, Giovanni, Visciano, Christian, Bellomo, Rosa Grazia, Saggini, Raoul, Ferretti, Antonio
Format: Article
Language:English
Subjects:
631/378/2649/1310
631/378/2649/1723
Adult
Attention
Back pain
Brain - diagnostic imaging
Brain mapping
Brain research
Female
Functional magnetic resonance imaging
Handedness
Humanities and Social Sciences
Humans
Interoception - physiology
Low back pain
Low Back Pain - therapy
Magnetic Resonance Imaging
Male
Manipulation, Osteopathic - methods
Manipulative therapy
Middle Aged
multidisciplinary
Neostriatum
Neurobiology
Neurosciences
Orthopedics
Osteopathic medicine
Pain Measurement
Perception
Physiology
Science
Science (multidisciplinary)
Young Adult
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Summary:The present randomised placebo controlled trial explored the extent to which osteopathic manipulative treatment (OMT) affects brain activity, particularly the insula, during both an “interoceptive awareness” and “exteroceptive awareness” task in a sample of 32 right-handed adults with chronic Low Back Pain (CLBP) randomly assigned to either the OMT or sham group. Patients received 4 weekly sessions and fMRI was performed at enrolment (T0), immediately after the first session (T1) and at 1 month (T2). The results revealed that the OMT produced a distinct and specific reduction in BOLD response in specific brain areas related to interoception, i.e., bilateral insula, ACC, left striatum and rMFG. The observed trend across the three time points appears uncharacteristic. At T1, a marginal increase of the BOLD response was observed in all the above-mentioned areas except the rMFG, which showed a decrease in BOLD response. At T2, the response was the opposite: areas related to interoception (bilateral insula and ACC) as well as the rMFG and left striatum demonstrated significant decreased in BOLD response. The findings of this study provide an insight into the effects of manual therapies on brain activity and have implications for future research in the field.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-60253-6