Serum Fibroblast Growth Factor 19 and Total Bile Acid Concentrations Are Potential Biomarkers of Hepatocellular Carcinoma in Patients with Type 2 Diabetes Mellitus

Purpose. Type 2 diabetes mellitus (T2DM) carries a high risk of hepatocellular carcinoma (HCC). Both serum fibroblast growth factor 19 (FGF19) and bile acid concentrations are associated with T2DM and HCC. We aimed at evaluating the relationships between FGF19 and bile acid concentrations and HCC in...

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Published in:BioMed research international 2020, Vol.2020 (2020), p.1-9
Main Authors: Wang, Xinlei, Yuan, Jin, OuYang, Rong, Zhang, Rongping, Chen, Wei, Gu, Yunjuan, Sun, Yezi, Cui, Shiwei, Huang, Hua, Su, Jianyou, Chang, Renan, Ni, Xiaoqing, Zhao, Hui, Zhu, Minxia, Sun, Yi, Yuan, Jie
Format: Article
Language:English
Subjects:
Acids
Adolescent
Adult
Age
Aged
Analysis
Bile
Bile acids
Bile Acids and Salts - metabolism
Biomarkers
Biomarkers, Tumor - blood
Blood pressure
Body mass index
Carcinoma, Hepatocellular - blood
Carcinoma, Hepatocellular - pathology
Chemotherapy
Cholesterol
Control methods
Correlation analysis
Deoxycholic acid
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - pathology
Female
Fibroblast growth factors
Fibroblast Growth Factors - blood
Fibroblasts
Growth factors
Hepatocellular carcinoma
Hepatoma
Humans
Insulin resistance
Laboratories
Liver cancer
Liver Neoplasms - blood
Liver Neoplasms - pathology
Male
Metabolism
Middle Aged
Neoplasm Proteins - blood
Pathogenesis
Regression analysis
Type 2 diabetes
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Summary:Purpose. Type 2 diabetes mellitus (T2DM) carries a high risk of hepatocellular carcinoma (HCC). Both serum fibroblast growth factor 19 (FGF19) and bile acid concentrations are associated with T2DM and HCC. We aimed at evaluating the relationships between FGF19 and bile acid concentrations and HCC in patients with T2DM. Methods. Twenty-seven healthy volunteers (control group), 27 patients with T2DM (T2DM group), 16 patients with newly diagnosed HCC (HCC group), and 10 T2DM patients with newly diagnosed HCC (T2DM-HCC group) were studied at the Affiliated Hospital of Nantong University between June 2016 and June 2017. The serum concentrations of serum FGF19 and total bile acids (TBA) were measured in all the participants. Correlation analysis and multiple stepwise regression analysis of the FGF19 and TBA concentrations were performed in all the participants and in the four groups. Results. The concentrations of FGF19 were 220.5 pg/ml, 185.1 pg/ml, 115.8 pg/ml, and 70.4 pg/ml in the HCC, T2DM-HCC, control, and T2DM groups, respectively (p
ISSN:2314-6133
2314-6141
DOI:10.1155/2020/1751989