A Unique Regulation Region in the 3' UTR of HLA-G with a Promising Potential

Human leukocyte antigen G (HLA-G) is a non-classical human leukocyte antigen (HLA) class I protein that interacts with inhibitory receptors and is commonly overexpressed in various cancers, thereby establishing itself as an inhibitory checkpoint immune ligand. It is also expressed in trophoblast cel...

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Bibliographic Details
Published in:International journal of molecular sciences 2020-01, Vol.21 (3), p.900
Main Authors: Reches, Adi, Berhani, Orit, Mandelboim, Ofer
Format: Article
Language:English
Subjects:
Binding
Binding sites
Fetuses
Histocompatibility antigen HLA
Immune system
Immunoglobulins
Lymphocytes
Mass spectrometry
miRNA
Post-transcription
Protein expression
Proteins
Regulation
RNA-binding protein
Scientific imaging
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Summary:Human leukocyte antigen G (HLA-G) is a non-classical human leukocyte antigen (HLA) class I protein that interacts with inhibitory receptors and is commonly overexpressed in various cancers, thereby establishing itself as an inhibitory checkpoint immune ligand. It is also expressed in trophoblast cells during pregnancy and protects the fetus from immune rejection. Despite its crucial role and its intriguing expression pattern, the regulation of HLA-G's expression is only partially understood. HLA-G's mRNA is expressed in many tissues but the protein expression is restricted only to the cells mentioned above. Therefore, we suggest that HLA-G is post-transcriptionally regulated. Here, we reveal a distinctive site present only in the 3' Untranslated region (UTR) of HLA-G, which might explain its unique expression pattern. Consequently, we attempted to find binding factors such as RNA binding proteins (RBPs) and microRNAS (miRs) that regulate HLA-G expression by interacting with this distinct site present in its 3' UTR. Our research indicates that this site should be further studied in order to reveal its significance.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms21030900