Piece by piece: Building a ribozyme

The ribosome and RNase P are cellular ribonucleoprotein complexes that perform peptide bond synthesis and phosphodiester bond cleavage, respectively. Both are ancient biological assemblies that were already present in the last universal common ancestor of all life. The large subunit rRNA in the ribo...

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Bibliographic Details
Published in:The Journal of biological chemistry 2020-02, Vol.295 (8), p.2313-2323
Main Authors: Gray, Michael W., Gopalan, Venkat
Format: Article
Language:English
Subjects:
enzyme catalysis
evolution
Evolution, Molecular
JBC Reviews
Models, Molecular
ribonuclease P (RNase P)
Ribonuclease P - metabolism
ribonucleoprotein complex
ribosome
ribozyme (catalytic RNA) (RNA enzyme)
RNA, Catalytic - metabolism
RNA, Ribosomal - metabolism
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Summary:The ribosome and RNase P are cellular ribonucleoprotein complexes that perform peptide bond synthesis and phosphodiester bond cleavage, respectively. Both are ancient biological assemblies that were already present in the last universal common ancestor of all life. The large subunit rRNA in the ribosome and the RNA subunit of RNase P are the ribozyme components required for catalysis. Here, we explore the idea that these two large ribozymes may have begun their evolutionary odyssey as an assemblage of RNA “fragments” smaller than the contemporary full-length versions and that they transitioned through distinct stages along a pathway that may also be relevant for the evolution of other non-coding RNAs.
ISSN:0021-9258
1083-351X
DOI:10.1074/jbc.REV119.009929