Evaluation of the Healing Effects of Hypericum perforatum and Curcumin on Burn Wounds in Rats

Background. For centuries, medicinal plants have been extensively used in wound healing of burn injuries. The aim of this study is to analyze comparatively the effects of curcumin and Hypericum perforatum (HP) on second-degree burn wounds in rats. Materials and Methods. This experimental study was c...

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Bibliographic Details
Published in:Evidence-based complementary and alternative medicine 2020, Vol.2020 (2020), p.1-5
Main Author: Seyhan, Nevra
Format: Article
Language:English
Subjects:
Angiogenesis
Antimicrobial agents
Antioxidants
Biopsy
Burns
Burns and scalds
Care and treatment
Curcumin
Fibrosis
Flavonoids
Hypericum perforatum
Injuries
Medicinal plants
Medicine, Botanic
Medicine, Herbal
Natural products
Povidone
Statistical analysis
Wound healing
Wounds and injuries
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Summary:Background. For centuries, medicinal plants have been extensively used in wound healing of burn injuries. The aim of this study is to analyze comparatively the effects of curcumin and Hypericum perforatum (HP) on second-degree burn wounds in rats. Materials and Methods. This experimental study was conducted on 24 male Sprague-Dawley rats with second-degree burns. The animals were randomly divided into three groups. The burns were treated with curcumin (Group B) and Hypericum perforatum (Group C) with daily application. Group A was considered as the control group and received no medication. Histological parameters, reepithelization, granulation tissue formation, inflammation, and angiogenesis were assessed after the scar biopsy at the end of research. Results. All histological parameters of the control group showed statistically significant difference than the other groups (p
ISSN:1741-427X
1741-4288
DOI:10.1155/2020/6462956