Evaluation of the Healing Effects of Hypericum perforatum and Curcumin on Burn Wounds in Rats

Background. For centuries, medicinal plants have been extensively used in wound healing of burn injuries. The aim of this study is to analyze comparatively the effects of curcumin and Hypericum perforatum (HP) on second-degree burn wounds in rats. Materials and Methods. This experimental study was c...

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Published in:Evidence-based complementary and alternative medicine 2020, Vol.2020 (2020), p.1-5
Main Author: Seyhan, Nevra
Format: Article
Language:English
Subjects:
Angiogenesis
Antimicrobial agents
Antioxidants
Biopsy
Burns
Burns and scalds
Care and treatment
Curcumin
Fibrosis
Flavonoids
Hypericum perforatum
Injuries
Medicinal plants
Medicine, Botanic
Medicine, Herbal
Natural products
Povidone
Statistical analysis
Wound healing
Wounds and injuries
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description Background. For centuries, medicinal plants have been extensively used in wound healing of burn injuries. The aim of this study is to analyze comparatively the effects of curcumin and Hypericum perforatum (HP) on second-degree burn wounds in rats. Materials and Methods. This experimental study was conducted on 24 male Sprague-Dawley rats with second-degree burns. The animals were randomly divided into three groups. The burns were treated with curcumin (Group B) and Hypericum perforatum (Group C) with daily application. Group A was considered as the control group and received no medication. Histological parameters, reepithelization, granulation tissue formation, inflammation, and angiogenesis were assessed after the scar biopsy at the end of research. Results. All histological parameters of the control group showed statistically significant difference than the other groups (p
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For centuries, medicinal plants have been extensively used in wound healing of burn injuries. The aim of this study is to analyze comparatively the effects of curcumin and Hypericum perforatum (HP) on second-degree burn wounds in rats. Materials and Methods. This experimental study was conducted on 24 male Sprague-Dawley rats with second-degree burns. The animals were randomly divided into three groups. The burns were treated with curcumin (Group B) and Hypericum perforatum (Group C) with daily application. Group A was considered as the control group and received no medication. Histological parameters, reepithelization, granulation tissue formation, inflammation, and angiogenesis were assessed after the scar biopsy at the end of research. Results. All histological parameters of the control group showed statistically significant difference than the other groups (p&lt;0.05). There was no statistically significant difference between Groups B and C in terms of reepithelization and inflammation (p=0.351, p=0.067). In the curcumin group compared with the HP group, a significant difference was observed for two parameters of fibrosis and angiogenesis (p&lt;0.05). Conclusion. Both curcumin and Hypericum perforatum oil are effective in burn wound healing. Our findings showed a better quality of healing in curcumin-treated rats.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2020/6462956</identifier><identifier>PMID: 32148546</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Angiogenesis ; Antimicrobial agents ; Antioxidants ; Biopsy ; Burns ; Burns and scalds ; Care and treatment ; Curcumin ; Fibrosis ; Flavonoids ; Hypericum perforatum ; Injuries ; Medicinal plants ; Medicine, Botanic ; Medicine, Herbal ; Natural products ; Povidone ; Statistical analysis ; Wound healing ; Wounds and injuries</subject><ispartof>Evidence-based complementary and alternative medicine, 2020, Vol.2020 (2020), p.1-5</ispartof><rights>Copyright © 2020 Nevra Seyhan.</rights><rights>COPYRIGHT 2020 John Wiley &amp; Sons, Inc.</rights><rights>Copyright © 2020 Nevra Seyhan. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 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For centuries, medicinal plants have been extensively used in wound healing of burn injuries. The aim of this study is to analyze comparatively the effects of curcumin and Hypericum perforatum (HP) on second-degree burn wounds in rats. Materials and Methods. This experimental study was conducted on 24 male Sprague-Dawley rats with second-degree burns. The animals were randomly divided into three groups. The burns were treated with curcumin (Group B) and Hypericum perforatum (Group C) with daily application. Group A was considered as the control group and received no medication. Histological parameters, reepithelization, granulation tissue formation, inflammation, and angiogenesis were assessed after the scar biopsy at the end of research. Results. All histological parameters of the control group showed statistically significant difference than the other groups (p&lt;0.05). There was no statistically significant difference between Groups B and C in terms of reepithelization and inflammation (p=0.351, p=0.067). In the curcumin group compared with the HP group, a significant difference was observed for two parameters of fibrosis and angiogenesis (p&lt;0.05). Conclusion. Both curcumin and Hypericum perforatum oil are effective in burn wound healing. 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For centuries, medicinal plants have been extensively used in wound healing of burn injuries. The aim of this study is to analyze comparatively the effects of curcumin and Hypericum perforatum (HP) on second-degree burn wounds in rats. Materials and Methods. This experimental study was conducted on 24 male Sprague-Dawley rats with second-degree burns. The animals were randomly divided into three groups. The burns were treated with curcumin (Group B) and Hypericum perforatum (Group C) with daily application. Group A was considered as the control group and received no medication. Histological parameters, reepithelization, granulation tissue formation, inflammation, and angiogenesis were assessed after the scar biopsy at the end of research. Results. All histological parameters of the control group showed statistically significant difference than the other groups (p&lt;0.05). 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subjects Angiogenesis
Antimicrobial agents
Antioxidants
Biopsy
Burns
Burns and scalds
Care and treatment
Curcumin
Fibrosis
Flavonoids
Hypericum perforatum
Injuries
Medicinal plants
Medicine, Botanic
Medicine, Herbal
Natural products
Povidone
Statistical analysis
Wound healing
Wounds and injuries
title Evaluation of the Healing Effects of Hypericum perforatum and Curcumin on Burn Wounds in Rats
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