Unwinding 20 Years of the Archaeal Minichromosome Maintenance Helicase

Replicative DNA helicases are essential cellular enzymes that unwind duplex DNA in front of the replication fork during chromosomal DNA replication. Replicative helicases were discovered, beginning in the 1970s, in bacteria, bacteriophages, viruses, and eukarya, and, in the mid-1990s, in archaea. Th...

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Bibliographic Details
Published in:Journal of bacteriology 2020-02, Vol.202 (6)
Main Authors: Kelman, Lori M, O'Dell, William B, Kelman, Zvi
Format: Article
Language:English
Subjects:
Archaea
Bacteriology
Deoxyribonucleic acid
DNA
DNA biosynthesis
DNA helicase
Maintenance
Minireview
Phages
Replication
Unwinding
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Summary:Replicative DNA helicases are essential cellular enzymes that unwind duplex DNA in front of the replication fork during chromosomal DNA replication. Replicative helicases were discovered, beginning in the 1970s, in bacteria, bacteriophages, viruses, and eukarya, and, in the mid-1990s, in archaea. This year marks the 20th anniversary of the first report on the archaeal replicative helicase, the minichromosome maintenance (MCM) protein. This minireview summarizes 2 decades of work on the archaeal MCM.
ISSN:0021-9193
1098-5530
DOI:10.1128/JB.00729-19