Gastrointestinal motility, dysbiosis and opioid-induced tolerance: is there a link?

Studies show that gut microbial dysbiosis induced by chronic opioid use is linked to central opioid tolerance. Here, we suggest that a persistent decrease in gastrointestinal motility by opioids is a primary cause of gut microbial dysbiosis and that improving gastrointestinal transit might be a stra...

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Bibliographic Details
Published in:Nature reviews. Gastroenterology & hepatology 2019-06, Vol.16 (6), p.323-324
Main Authors: Akbarali, Hamid I., Dewey, William L.
Format: Article
Language:English
Subjects:
631/154/1438
692/4020/1503/2745
692/4020/1503/2753
692/4020/2741/2135
Analgesics, Opioid - adverse effects
Animals
Biomedicine
Chronic diseases
Comment
Complications and side effects
Development and progression
Digestive system
Drug therapy
Drug Tolerance
Dysbacteriosis
Dysbiosis
Dysbiosis - etiology
Dysbiosis - microbiology
Dysbiosis - physiopathology
Gastric motility
Gastroenterology
Gastrointestinal Microbiome - drug effects
Gastrointestinal Motility - drug effects
Gastrointestinal system
Gastrointestinal tract
Health aspects
Hepatology
Humans
Intestinal microflora
Medicine
Medicine & Public Health
Microbiota (Symbiotic organisms)
Morphine
Motility
Narcotics
Opioids
Physiological aspects
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Description
Summary:Studies show that gut microbial dysbiosis induced by chronic opioid use is linked to central opioid tolerance. Here, we suggest that a persistent decrease in gastrointestinal motility by opioids is a primary cause of gut microbial dysbiosis and that improving gastrointestinal transit might be a strategy in preventing opioid analgesic tolerance.
ISSN:1759-5045
1759-5053
1759-5053
DOI:10.1038/s41575-019-0150-x