Chemical constituents, antioxidant and cytotoxicity properties of Leonotisleonurus used in the folklore management of neurological disorders in the Eastern Cape, South Africa

In the present study, we evaluated the phytochemical compounds and antioxidant properties of chloroform, ethanol and acetone extracts for leaves and flowers of Leonutus leonurus ( L. leonurus ) alongside with their cytotoxic effects on human cervical carcinoma (HeLa) cell lines. The phytochemical co...

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Bibliographic Details
Published in:3 Biotech 2020-02, Vol.10 (3)
Main Authors: Tonisi, Sipho, Okaiyeto, Kunle, Hoppe, Heinrich, Mabinya, Leonard V., Nwodo, Uchechukwu U., Okoh, Anthony I.
Format: Article
Language:English
Subjects:
Acetone
Agriculture
Alkaloids
Anticancer properties
Antioxidants
Antitumor agents
Bioactive compounds
Biocompatibility
Bioinformatics
Biomaterials
Biotechnology
Cancer Research
Cervical cancer
Cervical carcinoma
Cervix
Chelation
Chemistry
Chemistry and Materials Science
Chloroform
Cytotoxicity
Ethanol
Flavonoids
Flowers
Gas chromatography
Hydrogen peroxide
Mass spectrometry
Mass spectroscopy
Neurological diseases
Neuroprotection
Nitric oxide
Organic chemistry
Original
Original Article
Phytochemicals
Scavenging
Stem Cells
Toxicity
Tumor cell lines
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Summary:In the present study, we evaluated the phytochemical compounds and antioxidant properties of chloroform, ethanol and acetone extracts for leaves and flowers of Leonutus leonurus ( L. leonurus ) alongside with their cytotoxic effects on human cervical carcinoma (HeLa) cell lines. The phytochemical compounds present in the leaves and flowers of L. leonurus included; phenolics, flavonoids and alkaloids. Their radicals scavenging effects against 2, 2-diphenyl-1-picrylhydrazyl [DPPH] 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulphonate) [ABTS· + ], hydrogen peroxide, nitric oxide as well as metal chelating activities showed dose-dependent activities. Gas chromatography-mass spectrometry (GCMS) analyses revealed the presence of important bioactive compounds, which are associated with antioxidant; and the extracts exhibited toxicity effect against HeLa cells. The findings from this study divulge extracts of L. leonurus as prospective sources of antioxidant and anticancer agents; and hence, further study on their neuroprotective potentials becomes imperative.
ISSN:2190-572X
2190-5738
DOI:10.1007/s13205-020-2126-5