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Chemical constituents, antioxidant and cytotoxicity properties of Leonotisleonurus used in the folklore management of neurological disorders in the Eastern Cape, South Africa
In the present study, we evaluated the phytochemical compounds and antioxidant properties of chloroform, ethanol and acetone extracts for leaves and flowers of Leonutus leonurus ( L. leonurus ) alongside with their cytotoxic effects on human cervical carcinoma (HeLa) cell lines. The phytochemical co...
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| Published in: | 3 Biotech 2020-02, Vol.10 (3) |
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| creator | Tonisi, Sipho Okaiyeto, Kunle Hoppe, Heinrich Mabinya, Leonard V. Nwodo, Uchechukwu U. Okoh, Anthony I. |
| description | In the present study, we evaluated the phytochemical compounds and antioxidant properties of chloroform, ethanol and acetone extracts for leaves and flowers of
Leonutus
leonurus
(
L.
leonurus
) alongside with their cytotoxic effects on human cervical carcinoma (HeLa) cell lines. The phytochemical compounds present in the leaves and flowers of
L.
leonurus
included; phenolics, flavonoids and alkaloids. Their radicals scavenging effects against 2, 2-diphenyl-1-picrylhydrazyl [DPPH] 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulphonate) [ABTS·
+
], hydrogen peroxide, nitric oxide as well as metal chelating activities showed dose-dependent activities. Gas chromatography-mass spectrometry (GCMS) analyses revealed the presence of important bioactive compounds, which are associated with antioxidant; and the extracts exhibited toxicity effect against HeLa cells. The findings from this study divulge extracts of
L.
leonurus
as prospective sources of antioxidant and anticancer agents; and hence, further study on their neuroprotective potentials becomes imperative. |
| doi_str_mv | 10.1007/s13205-020-2126-5 |
| format | article |
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Leonutus
leonurus
(
L.
leonurus
) alongside with their cytotoxic effects on human cervical carcinoma (HeLa) cell lines. The phytochemical compounds present in the leaves and flowers of
L.
leonurus
included; phenolics, flavonoids and alkaloids. Their radicals scavenging effects against 2, 2-diphenyl-1-picrylhydrazyl [DPPH] 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulphonate) [ABTS·
+
], hydrogen peroxide, nitric oxide as well as metal chelating activities showed dose-dependent activities. Gas chromatography-mass spectrometry (GCMS) analyses revealed the presence of important bioactive compounds, which are associated with antioxidant; and the extracts exhibited toxicity effect against HeLa cells. The findings from this study divulge extracts of
L.
leonurus
as prospective sources of antioxidant and anticancer agents; and hence, further study on their neuroprotective potentials becomes imperative.</description><identifier>ISSN: 2190-572X</identifier><identifier>EISSN: 2190-5738</identifier><identifier>DOI: 10.1007/s13205-020-2126-5</identifier><identifier>PMID: 32206490</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Acetone ; Agriculture ; Alkaloids ; Anticancer properties ; Antioxidants ; Antitumor agents ; Bioactive compounds ; Biocompatibility ; Bioinformatics ; Biomaterials ; Biotechnology ; Cancer Research ; Cervical cancer ; Cervical carcinoma ; Cervix ; Chelation ; Chemistry ; Chemistry and Materials Science ; Chloroform ; Cytotoxicity ; Ethanol ; Flavonoids ; Flowers ; Gas chromatography ; Hydrogen peroxide ; Mass spectrometry ; Mass spectroscopy ; Neurological diseases ; Neuroprotection ; Nitric oxide ; Organic chemistry ; Original ; Original Article ; Phytochemicals ; Scavenging ; Stem Cells ; Toxicity ; Tumor cell lines</subject><ispartof>3 Biotech, 2020-02, Vol.10 (3)</ispartof><rights>The Author(s) 2020</rights><rights>This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-p211t-f5599dfc1aa1ddac39649a5aa050f8e84f55eb554a4d566f8de5483a582325dc3</cites><orcidid>0000-0002-7211-714X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046865/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046865/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids></links><search><creatorcontrib>Tonisi, Sipho</creatorcontrib><creatorcontrib>Okaiyeto, Kunle</creatorcontrib><creatorcontrib>Hoppe, Heinrich</creatorcontrib><creatorcontrib>Mabinya, Leonard V.</creatorcontrib><creatorcontrib>Nwodo, Uchechukwu U.</creatorcontrib><creatorcontrib>Okoh, Anthony I.</creatorcontrib><title>Chemical constituents, antioxidant and cytotoxicity properties of Leonotisleonurus used in the folklore management of neurological disorders in the Eastern Cape, South Africa</title><title>3 Biotech</title><addtitle>3 Biotech</addtitle><description>In the present study, we evaluated the phytochemical compounds and antioxidant properties of chloroform, ethanol and acetone extracts for leaves and flowers of
Leonutus
leonurus
(
L.
leonurus
) alongside with their cytotoxic effects on human cervical carcinoma (HeLa) cell lines. The phytochemical compounds present in the leaves and flowers of
L.
leonurus
included; phenolics, flavonoids and alkaloids. Their radicals scavenging effects against 2, 2-diphenyl-1-picrylhydrazyl [DPPH] 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulphonate) [ABTS·
+
], hydrogen peroxide, nitric oxide as well as metal chelating activities showed dose-dependent activities. Gas chromatography-mass spectrometry (GCMS) analyses revealed the presence of important bioactive compounds, which are associated with antioxidant; and the extracts exhibited toxicity effect against HeLa cells. The findings from this study divulge extracts of
L.
leonurus
as prospective sources of antioxidant and anticancer agents; and hence, further study on their neuroprotective potentials becomes imperative.</description><subject>Acetone</subject><subject>Agriculture</subject><subject>Alkaloids</subject><subject>Anticancer properties</subject><subject>Antioxidants</subject><subject>Antitumor agents</subject><subject>Bioactive compounds</subject><subject>Biocompatibility</subject><subject>Bioinformatics</subject><subject>Biomaterials</subject><subject>Biotechnology</subject><subject>Cancer Research</subject><subject>Cervical cancer</subject><subject>Cervical carcinoma</subject><subject>Cervix</subject><subject>Chelation</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chloroform</subject><subject>Cytotoxicity</subject><subject>Ethanol</subject><subject>Flavonoids</subject><subject>Flowers</subject><subject>Gas chromatography</subject><subject>Hydrogen peroxide</subject><subject>Mass spectrometry</subject><subject>Mass spectroscopy</subject><subject>Neurological diseases</subject><subject>Neuroprotection</subject><subject>Nitric oxide</subject><subject>Organic chemistry</subject><subject>Original</subject><subject>Original Article</subject><subject>Phytochemicals</subject><subject>Scavenging</subject><subject>Stem Cells</subject><subject>Toxicity</subject><subject>Tumor cell lines</subject><issn>2190-572X</issn><issn>2190-5738</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNpVkctqHDEQRUVIiI3jD8hOkK3b0aPVj03ADE5sGMgiCWQnyq3qGTndUlsP4_kpf6M1Hicm2txCdeqqxCXkI2fnnLH2c-RSMFUxwSrBRVOpN-RY8J5VqpXd23-1-H1ETmO8ZeUornrO3pMjKQRr6p4dk8fVFmc7wEQH72KyKaNL8YyCS9Y_WFO01IYOu-RTuRhs2tEl-AVDshipH-kavfPJxqloDjnSHNFQ62jaIh399GfyAekMDjY4F_f9jMMc_OQ3zy8bG30wGOLfoUuICYOjK1jwjP7wOW3pxRgK_IG8G2GKePqiJ-TX18ufq6tq_f3b9epiXS2C81SNSvW9GQcOwI2BQfblt6AAmGJjh11dALxRqobaqKYZO4Oq7iSoTkihzCBPyJeD75JvZjRDWTvApJdgZwg77cHq_zvObvXG3-uW1U3XqGLw6cUg-LuMMelbn4MrO2shS78WbcsKJQ5ULM5ug-GV4kzvY9aHmHWJWe9j1ko-AVWjn2g</recordid><startdate>20200227</startdate><enddate>20200227</enddate><creator>Tonisi, Sipho</creator><creator>Okaiyeto, Kunle</creator><creator>Hoppe, Heinrich</creator><creator>Mabinya, Leonard V.</creator><creator>Nwodo, Uchechukwu U.</creator><creator>Okoh, Anthony I.</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7211-714X</orcidid></search><sort><creationdate>20200227</creationdate><title>Chemical constituents, antioxidant and cytotoxicity properties of Leonotisleonurus used in the folklore management of neurological disorders in the Eastern Cape, South Africa</title><author>Tonisi, Sipho ; Okaiyeto, Kunle ; Hoppe, Heinrich ; Mabinya, Leonard V. ; Nwodo, Uchechukwu U. ; Okoh, Anthony I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p211t-f5599dfc1aa1ddac39649a5aa050f8e84f55eb554a4d566f8de5483a582325dc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acetone</topic><topic>Agriculture</topic><topic>Alkaloids</topic><topic>Anticancer properties</topic><topic>Antioxidants</topic><topic>Antitumor agents</topic><topic>Bioactive compounds</topic><topic>Biocompatibility</topic><topic>Bioinformatics</topic><topic>Biomaterials</topic><topic>Biotechnology</topic><topic>Cancer Research</topic><topic>Cervical cancer</topic><topic>Cervical carcinoma</topic><topic>Cervix</topic><topic>Chelation</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chloroform</topic><topic>Cytotoxicity</topic><topic>Ethanol</topic><topic>Flavonoids</topic><topic>Flowers</topic><topic>Gas chromatography</topic><topic>Hydrogen peroxide</topic><topic>Mass spectrometry</topic><topic>Mass spectroscopy</topic><topic>Neurological diseases</topic><topic>Neuroprotection</topic><topic>Nitric oxide</topic><topic>Organic chemistry</topic><topic>Original</topic><topic>Original Article</topic><topic>Phytochemicals</topic><topic>Scavenging</topic><topic>Stem Cells</topic><topic>Toxicity</topic><topic>Tumor cell lines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tonisi, Sipho</creatorcontrib><creatorcontrib>Okaiyeto, Kunle</creatorcontrib><creatorcontrib>Hoppe, Heinrich</creatorcontrib><creatorcontrib>Mabinya, Leonard V.</creatorcontrib><creatorcontrib>Nwodo, Uchechukwu U.</creatorcontrib><creatorcontrib>Okoh, Anthony I.</creatorcontrib><collection>Springer_OA刊</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>3 Biotech</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tonisi, Sipho</au><au>Okaiyeto, Kunle</au><au>Hoppe, Heinrich</au><au>Mabinya, Leonard V.</au><au>Nwodo, Uchechukwu U.</au><au>Okoh, Anthony I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chemical constituents, antioxidant and cytotoxicity properties of Leonotisleonurus used in the folklore management of neurological disorders in the Eastern Cape, South Africa</atitle><jtitle>3 Biotech</jtitle><stitle>3 Biotech</stitle><date>2020-02-27</date><risdate>2020</risdate><volume>10</volume><issue>3</issue><issn>2190-572X</issn><eissn>2190-5738</eissn><abstract>In the present study, we evaluated the phytochemical compounds and antioxidant properties of chloroform, ethanol and acetone extracts for leaves and flowers of
Leonutus
leonurus
(
L.
leonurus
) alongside with their cytotoxic effects on human cervical carcinoma (HeLa) cell lines. The phytochemical compounds present in the leaves and flowers of
L.
leonurus
included; phenolics, flavonoids and alkaloids. Their radicals scavenging effects against 2, 2-diphenyl-1-picrylhydrazyl [DPPH] 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulphonate) [ABTS·
+
], hydrogen peroxide, nitric oxide as well as metal chelating activities showed dose-dependent activities. Gas chromatography-mass spectrometry (GCMS) analyses revealed the presence of important bioactive compounds, which are associated with antioxidant; and the extracts exhibited toxicity effect against HeLa cells. The findings from this study divulge extracts of
L.
leonurus
as prospective sources of antioxidant and anticancer agents; and hence, further study on their neuroprotective potentials becomes imperative.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>32206490</pmid><doi>10.1007/s13205-020-2126-5</doi><orcidid>https://orcid.org/0000-0002-7211-714X</orcidid><oa>free_for_read</oa></addata></record> |
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| source | NCBI_PubMed Central（免费）; Springer Nature |
| subjects | Acetone Agriculture Alkaloids Anticancer properties Antioxidants Antitumor agents Bioactive compounds Biocompatibility Bioinformatics Biomaterials Biotechnology Cancer Research Cervical cancer Cervical carcinoma Cervix Chelation Chemistry Chemistry and Materials Science Chloroform Cytotoxicity Ethanol Flavonoids Flowers Gas chromatography Hydrogen peroxide Mass spectrometry Mass spectroscopy Neurological diseases Neuroprotection Nitric oxide Organic chemistry Original Original Article Phytochemicals Scavenging Stem Cells Toxicity Tumor cell lines |
| title | Chemical constituents, antioxidant and cytotoxicity properties of Leonotisleonurus used in the folklore management of neurological disorders in the Eastern Cape, South Africa |
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