The role of ADP-ribose metabolism in metabolic regulation, adipose tissue differentiation, and metabolism

Poly(ADP-ribose) polymerases (PARPs or ARTDs), originally described as DNA repair factors, have metabolic regulatory roles. PARP1, PARP2, PARP7, PARP10, and PARP14 regulate central and peripheral carbohydrate and lipid metabolism and often channel pathological disruptive metabolic signals. PARP1 and...

Full description

Saved in:
Bibliographic Details
Published in:Genes & development 2020-03, Vol.34 (5-6), p.321-340
Main Authors: Szántó, Magdolna, Bai, Peter
Format: Article
Language:English
Subjects:
Adenosine Diphosphate Ribose - metabolism
Adipose Tissue - cytology
Adipose Tissue - metabolism
Carbohydrate Metabolism
Cell Differentiation
Humans
Lipid Metabolism - physiology
Poly(ADP-ribose) Polymerases - metabolism
Special Section: Review
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Poly(ADP-ribose) polymerases (PARPs or ARTDs), originally described as DNA repair factors, have metabolic regulatory roles. PARP1, PARP2, PARP7, PARP10, and PARP14 regulate central and peripheral carbohydrate and lipid metabolism and often channel pathological disruptive metabolic signals. PARP1 and PARP2 are crucial for adipocyte differentiation, including the commitment toward white, brown, or beige adipose tissue lineages, as well as the regulation of lipid accumulation. Through regulating adipocyte function and organismal energy balance, PARPs play a role in obesity and the consequences of obesity. These findings can be translated into humans, as evidenced by studies on identical twins and SNPs affecting PARP activity.
ISSN:0890-9369
1549-5477
DOI:10.1101/gad.334284.119