Incidence and predictors of target lesion failure in patients undergoing contemporary DES implantation—Individual patient data pooled analysis from 6 randomized controlled trials

Drug-eluting stents (DESs) have improved clinical outcomes of patients undergoing percutaneous coronary intervention (PCI). Nevertheless, adverse events related to previously treated lesion still occur. We sought to evaluate the incidence and predictors of target lesion failure (TLF) in patients und...

Full description

Saved in:
Bibliographic Details
Published in:The American heart journal 2019-07, Vol.213, p.105-111
Main Authors: Konigstein, Maayan, Madhavan, Mahesh V., Ben-Yehuda, Ori, Rahim, Hussein M., Srdanovic, Iva, Gkargkoulas, Fotis, Mehdipoor, Ghazaleh, Shlofmitz, Evan, Maehara, Akiko, Redfors, Björn, Gore, Ankita K., McAndrew, Thomas, Stone, Gregg W., Ali, Ziad A.
Format: Article
Language:English
Subjects:
Acute coronary syndromes
Age
Antineoplastic Agents - therapeutic use
Blood vessels
Body mass index
Calcification
Clinical outcomes
Clinical trials
Coronary artery
Coronary Restenosis - therapy
Coronary vessels
Diabetes
Diabetes mellitus
Drug delivery
Drug-Eluting Stents - statistics & numerical data
Everolimus - therapeutic use
Failure analysis
Female
Grafting
Hazard identification
Heart attacks
Heart Diseases - mortality
Heart surgery
Humans
Hypertension
Implantation
Implants
Incidence
Ischemia
Male
Middle Aged
Myocardial infarction
Myocardial Infarction - etiology
Paclitaxel - therapeutic use
Patients
Percutaneous Coronary Intervention - methods
Percutaneous Coronary Intervention - statistics & numerical data
Polymers
Proportional Hazards Models
Prospective Studies
Prosthesis Failure
Randomization
Randomized Controlled Trials as Topic - statistics & numerical data
Stents
Surgical implants
Time Factors
Transplants & implants
Treatment Failure
Veins & arteries
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Drug-eluting stents (DESs) have improved clinical outcomes of patients undergoing percutaneous coronary intervention (PCI). Nevertheless, adverse events related to previously treated lesion still occur. We sought to evaluate the incidence and predictors of target lesion failure (TLF) in patients undergoing contemporary DES implantation. Patient-level data from 6 prospective, randomized trials were pooled, and DES treatment outcomes were analyzed at up to 5 years. Primary outcome was TLF (cardiac death, target lesion revascularization, or target vessel myocardial infarction). Cox proportional-hazards model was used to identify predictors of TLF. Overall, 10,072 patients were included in the analysis. TLF rate was 1.7%, 4.3%, and 11.9% at 30 days, 1 year, and 5 years, respectively. The only independent predictor of TLF at 30 days was stent length (hazard ratio [HR] 1.017, 95% CI 1.011-1.024, P 
ISSN:0002-8703
1097-6744
DOI:10.1016/j.ahj.2019.03.011