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Prognostic value of preoperative weight loss-adjusted body mass index on survival after esophagectomy for esophageal squamous cell carcinoma
The impact of body mass index (BMI) on survival in patients with esophageal squamous cell carcinoma (ESCC) undergoing surgery remains unclear. Therefore, a definition of clinically significant BMI in patients with ESCC is needed. To explore the impact of preoperative weight loss (PWL)-adjusted BMI o...
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| Published in: | World journal of gastroenterology : WJG 2020-02, Vol.26 (8), p.839-849 |
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| creator | Zhang, Han-Lu Yang, Yu-Shang Duan, Jia-Nan Shang, Qi-Xin He, Song-Lin Gu, Yi-Min Hu, Wei-Peng Wang, Wen-Ping Hu, Yang Wang, Yun Yuan, Yong Chen, Long-Qi |
| description | The impact of body mass index (BMI) on survival in patients with esophageal squamous cell carcinoma (ESCC) undergoing surgery remains unclear. Therefore, a definition of clinically significant BMI in patients with ESCC is needed.
To explore the impact of preoperative weight loss (PWL)-adjusted BMI on overall survival (OS) in patients undergoing surgery for ESCC.
This retrospective study consisted of 1545 patients who underwent curative resection for ESCC at West China Hospital of Sichuan University between August 2005 and December 2011. The relationship between PWL-adjusted BMI and OS was examined, and a multivariate analysis was performed and adjusted for age, sex, TNM stage and adjuvant therapy.
Trends of poor survival were observed for patients with increasing PWL and decreasing BMI. Patients with BMI ≥ 20.0 kg/m
and PWL < 8.8% were classified into Group 1 with the longest median OS (45.3 mo). Patients with BMI < 20.0 kg/m
and PWL < 8.8% were classified into Group 2 with a median OS of 29.5 mo. Patients with BMI ≥ 20.0 kg/m
and PWL ≥ 8.8% (HR = 1.9, 95%CI: 1.5-2.5), and patients with BMI < 20.0 kg/m
and PWL ≥ 8.8% (HR = 2.0, 95%CI: 1.6-2.6), were combined into Group 3 with a median OS of 20.1 mo. Patients in the three groups were associated with significantly different OS (
< 0.05). In multivariate analysis, PWL-adjusted BMI, TNM stage and adjuvant therapy were identified as independent prognostic factors.
PWL-adjusted BMI has an independent prognostic impact on OS in patients with ESCC undergoing surgery. BMI might be an indicator for patients with PWL < 8.8% rather than ≥ 8.8%. |
| doi_str_mv | 10.3748/wjg.v26.i8.839 |
| format | article |
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To explore the impact of preoperative weight loss (PWL)-adjusted BMI on overall survival (OS) in patients undergoing surgery for ESCC.
This retrospective study consisted of 1545 patients who underwent curative resection for ESCC at West China Hospital of Sichuan University between August 2005 and December 2011. The relationship between PWL-adjusted BMI and OS was examined, and a multivariate analysis was performed and adjusted for age, sex, TNM stage and adjuvant therapy.
Trends of poor survival were observed for patients with increasing PWL and decreasing BMI. Patients with BMI ≥ 20.0 kg/m
and PWL < 8.8% were classified into Group 1 with the longest median OS (45.3 mo). Patients with BMI < 20.0 kg/m
and PWL < 8.8% were classified into Group 2 with a median OS of 29.5 mo. Patients with BMI ≥ 20.0 kg/m
and PWL ≥ 8.8% (HR = 1.9, 95%CI: 1.5-2.5), and patients with BMI < 20.0 kg/m
and PWL ≥ 8.8% (HR = 2.0, 95%CI: 1.6-2.6), were combined into Group 3 with a median OS of 20.1 mo. Patients in the three groups were associated with significantly different OS (
< 0.05). In multivariate analysis, PWL-adjusted BMI, TNM stage and adjuvant therapy were identified as independent prognostic factors.
PWL-adjusted BMI has an independent prognostic impact on OS in patients with ESCC undergoing surgery. BMI might be an indicator for patients with PWL < 8.8% rather than ≥ 8.8%.]]></description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.v26.i8.839</identifier><identifier>PMID: 32148381</identifier><language>eng</language><publisher>United States: Baishideng Publishing Group Inc</publisher><subject>Aged ; Body Mass Index ; Chemotherapy, Adjuvant - mortality ; China ; Esophageal Neoplasms - mortality ; Esophageal Neoplasms - physiopathology ; Esophageal Neoplasms - surgery ; Esophageal Squamous Cell Carcinoma - mortality ; Esophageal Squamous Cell Carcinoma - physiopathology ; Esophageal Squamous Cell Carcinoma - surgery ; Esophagectomy - mortality ; Female ; Humans ; Male ; Middle Aged ; Neoplasm Staging ; Nutritional Status ; Predictive Value of Tests ; Preoperative Period ; Prognosis ; Retrospective Studies ; Retrospective Study ; Treatment Outcome ; Weight Loss</subject><ispartof>World journal of gastroenterology : WJG, 2020-02, Vol.26 (8), p.839-849</ispartof><rights>The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.</rights><rights>The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. 2020</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-1be9974313e8c3c9521839ea01a4c50642de95d699a3f83ac28a773a077948913</citedby><cites>FETCH-LOGICAL-c390t-1be9974313e8c3c9521839ea01a4c50642de95d699a3f83ac28a773a077948913</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052531/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052531/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32148381$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Han-Lu</creatorcontrib><creatorcontrib>Yang, Yu-Shang</creatorcontrib><creatorcontrib>Duan, Jia-Nan</creatorcontrib><creatorcontrib>Shang, Qi-Xin</creatorcontrib><creatorcontrib>He, Song-Lin</creatorcontrib><creatorcontrib>Gu, Yi-Min</creatorcontrib><creatorcontrib>Hu, Wei-Peng</creatorcontrib><creatorcontrib>Wang, Wen-Ping</creatorcontrib><creatorcontrib>Hu, Yang</creatorcontrib><creatorcontrib>Wang, Yun</creatorcontrib><creatorcontrib>Yuan, Yong</creatorcontrib><creatorcontrib>Chen, Long-Qi</creatorcontrib><title>Prognostic value of preoperative weight loss-adjusted body mass index on survival after esophagectomy for esophageal squamous cell carcinoma</title><title>World journal of gastroenterology : WJG</title><addtitle>World J Gastroenterol</addtitle><description><![CDATA[The impact of body mass index (BMI) on survival in patients with esophageal squamous cell carcinoma (ESCC) undergoing surgery remains unclear. Therefore, a definition of clinically significant BMI in patients with ESCC is needed.
To explore the impact of preoperative weight loss (PWL)-adjusted BMI on overall survival (OS) in patients undergoing surgery for ESCC.
This retrospective study consisted of 1545 patients who underwent curative resection for ESCC at West China Hospital of Sichuan University between August 2005 and December 2011. The relationship between PWL-adjusted BMI and OS was examined, and a multivariate analysis was performed and adjusted for age, sex, TNM stage and adjuvant therapy.
Trends of poor survival were observed for patients with increasing PWL and decreasing BMI. Patients with BMI ≥ 20.0 kg/m
and PWL < 8.8% were classified into Group 1 with the longest median OS (45.3 mo). Patients with BMI < 20.0 kg/m
and PWL < 8.8% were classified into Group 2 with a median OS of 29.5 mo. Patients with BMI ≥ 20.0 kg/m
and PWL ≥ 8.8% (HR = 1.9, 95%CI: 1.5-2.5), and patients with BMI < 20.0 kg/m
and PWL ≥ 8.8% (HR = 2.0, 95%CI: 1.6-2.6), were combined into Group 3 with a median OS of 20.1 mo. Patients in the three groups were associated with significantly different OS (
< 0.05). In multivariate analysis, PWL-adjusted BMI, TNM stage and adjuvant therapy were identified as independent prognostic factors.
PWL-adjusted BMI has an independent prognostic impact on OS in patients with ESCC undergoing surgery. BMI might be an indicator for patients with PWL < 8.8% rather than ≥ 8.8%.]]></description><subject>Aged</subject><subject>Body Mass Index</subject><subject>Chemotherapy, Adjuvant - mortality</subject><subject>China</subject><subject>Esophageal Neoplasms - mortality</subject><subject>Esophageal Neoplasms - physiopathology</subject><subject>Esophageal Neoplasms - surgery</subject><subject>Esophageal Squamous Cell Carcinoma - mortality</subject><subject>Esophageal Squamous Cell Carcinoma - physiopathology</subject><subject>Esophageal Squamous Cell Carcinoma - surgery</subject><subject>Esophagectomy - mortality</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Nutritional Status</subject><subject>Predictive Value of Tests</subject><subject>Preoperative Period</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Retrospective Study</subject><subject>Treatment Outcome</subject><subject>Weight Loss</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNpVkU1v1DAQhi1ERZfClSPykUuCP5K1fUFCFV9SJXpoz9asM8l6lcSpnaTd_8CPxquWAidL43femWdeQt5xVkpV6Y_3h65cxbb0utTSvCAbIbgphK7YS7LhjKnCSKHOyeuUDowJKWvxipxLwSstNd-QX9cxdGNIs3d0hX5BGlo6RQwTRpj9ivQefbefaR9SKqA5LGnGhu5Cc6QDpET92OADDSNNS1x9tqDQzhgppjDtoUM3h-FI2_C3kiXpboEhLIk67HvqIDo_hgHekLMW-oRvn94Lcvv1y83l9-Lq57cfl5-vCicNmwu-Q2NUJblE7aQzteCZHYFxqFzNtpVo0NTN1hiQrZbghAalJDClTKUNlxfk06PvtOwGbByOc4TeTtEPEI82gLf__4x-b7uwWsVqUcuTwYcngxjuFkyzHXw6scCIGcsKqeqaCVFVWVo-Sl3MF4zYPo_hzJ4itDlCmyO0XtuMkRve_7vcs_xPZvI3NYydDQ</recordid><startdate>20200228</startdate><enddate>20200228</enddate><creator>Zhang, Han-Lu</creator><creator>Yang, Yu-Shang</creator><creator>Duan, Jia-Nan</creator><creator>Shang, Qi-Xin</creator><creator>He, Song-Lin</creator><creator>Gu, Yi-Min</creator><creator>Hu, Wei-Peng</creator><creator>Wang, Wen-Ping</creator><creator>Hu, Yang</creator><creator>Wang, Yun</creator><creator>Yuan, Yong</creator><creator>Chen, Long-Qi</creator><general>Baishideng Publishing Group Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200228</creationdate><title>Prognostic value of preoperative weight loss-adjusted body mass index on survival after esophagectomy for esophageal squamous cell carcinoma</title><author>Zhang, Han-Lu ; Yang, Yu-Shang ; Duan, Jia-Nan ; Shang, Qi-Xin ; He, Song-Lin ; Gu, Yi-Min ; Hu, Wei-Peng ; Wang, Wen-Ping ; Hu, Yang ; Wang, Yun ; Yuan, Yong ; Chen, Long-Qi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-1be9974313e8c3c9521839ea01a4c50642de95d699a3f83ac28a773a077948913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aged</topic><topic>Body Mass Index</topic><topic>Chemotherapy, Adjuvant - mortality</topic><topic>China</topic><topic>Esophageal Neoplasms - mortality</topic><topic>Esophageal Neoplasms - physiopathology</topic><topic>Esophageal Neoplasms - surgery</topic><topic>Esophageal Squamous Cell Carcinoma - mortality</topic><topic>Esophageal Squamous Cell Carcinoma - physiopathology</topic><topic>Esophageal Squamous Cell Carcinoma - surgery</topic><topic>Esophagectomy - mortality</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Nutritional Status</topic><topic>Predictive Value of Tests</topic><topic>Preoperative Period</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Retrospective Study</topic><topic>Treatment Outcome</topic><topic>Weight Loss</topic><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Han-Lu</creatorcontrib><creatorcontrib>Yang, Yu-Shang</creatorcontrib><creatorcontrib>Duan, Jia-Nan</creatorcontrib><creatorcontrib>Shang, Qi-Xin</creatorcontrib><creatorcontrib>He, Song-Lin</creatorcontrib><creatorcontrib>Gu, Yi-Min</creatorcontrib><creatorcontrib>Hu, Wei-Peng</creatorcontrib><creatorcontrib>Wang, Wen-Ping</creatorcontrib><creatorcontrib>Hu, Yang</creatorcontrib><creatorcontrib>Wang, Yun</creatorcontrib><creatorcontrib>Yuan, Yong</creatorcontrib><creatorcontrib>Chen, Long-Qi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of gastroenterology : WJG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Han-Lu</au><au>Yang, Yu-Shang</au><au>Duan, Jia-Nan</au><au>Shang, Qi-Xin</au><au>He, Song-Lin</au><au>Gu, Yi-Min</au><au>Hu, Wei-Peng</au><au>Wang, Wen-Ping</au><au>Hu, Yang</au><au>Wang, Yun</au><au>Yuan, Yong</au><au>Chen, Long-Qi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic value of preoperative weight loss-adjusted body mass index on survival after esophagectomy for esophageal squamous cell carcinoma</atitle><jtitle>World journal of gastroenterology : WJG</jtitle><addtitle>World J Gastroenterol</addtitle><date>2020-02-28</date><risdate>2020</risdate><volume>26</volume><issue>8</issue><spage>839</spage><epage>849</epage><pages>839-849</pages><issn>1007-9327</issn><eissn>2219-2840</eissn><abstract><![CDATA[The impact of body mass index (BMI) on survival in patients with esophageal squamous cell carcinoma (ESCC) undergoing surgery remains unclear. Therefore, a definition of clinically significant BMI in patients with ESCC is needed.
To explore the impact of preoperative weight loss (PWL)-adjusted BMI on overall survival (OS) in patients undergoing surgery for ESCC.
This retrospective study consisted of 1545 patients who underwent curative resection for ESCC at West China Hospital of Sichuan University between August 2005 and December 2011. The relationship between PWL-adjusted BMI and OS was examined, and a multivariate analysis was performed and adjusted for age, sex, TNM stage and adjuvant therapy.
Trends of poor survival were observed for patients with increasing PWL and decreasing BMI. Patients with BMI ≥ 20.0 kg/m
and PWL < 8.8% were classified into Group 1 with the longest median OS (45.3 mo). Patients with BMI < 20.0 kg/m
and PWL < 8.8% were classified into Group 2 with a median OS of 29.5 mo. Patients with BMI ≥ 20.0 kg/m
and PWL ≥ 8.8% (HR = 1.9, 95%CI: 1.5-2.5), and patients with BMI < 20.0 kg/m
and PWL ≥ 8.8% (HR = 2.0, 95%CI: 1.6-2.6), were combined into Group 3 with a median OS of 20.1 mo. Patients in the three groups were associated with significantly different OS (
< 0.05). In multivariate analysis, PWL-adjusted BMI, TNM stage and adjuvant therapy were identified as independent prognostic factors.
PWL-adjusted BMI has an independent prognostic impact on OS in patients with ESCC undergoing surgery. BMI might be an indicator for patients with PWL < 8.8% rather than ≥ 8.8%.]]></abstract><cop>United States</cop><pub>Baishideng Publishing Group Inc</pub><pmid>32148381</pmid><doi>10.3748/wjg.v26.i8.839</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Body Mass Index Chemotherapy, Adjuvant - mortality China Esophageal Neoplasms - mortality Esophageal Neoplasms - physiopathology Esophageal Neoplasms - surgery Esophageal Squamous Cell Carcinoma - mortality Esophageal Squamous Cell Carcinoma - physiopathology Esophageal Squamous Cell Carcinoma - surgery Esophagectomy - mortality Female Humans Male Middle Aged Neoplasm Staging Nutritional Status Predictive Value of Tests Preoperative Period Prognosis Retrospective Studies Retrospective Study Treatment Outcome Weight Loss |
| title | Prognostic value of preoperative weight loss-adjusted body mass index on survival after esophagectomy for esophageal squamous cell carcinoma |
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