Neural maturation enhanced by exercise-induced extracellular derivatives

• Published in: Scientific reports 2020-03, Vol.10 (1), p.3893-3893, Article 3893
• Main Authors: Moon, Hyo Youl, Yoon, Kyeong Jin, Lee, Won Sang, Cho, Hae-Sung, Kim, Do-Yeon, Kim, Ji-Seok
• Format: Article
• Language: English
• Subjects: 1-Phosphatidylinositol 3-kinase; 13; 13/21; 13/95; 38; 38/77; 38/91; 631/443/376; 64/60; 692/4017; AKT protein; Animals; Brain - cytology; Brain - growth & development; Brain - physiology; Cell differentiation; Cell Line; Cell Proliferation; Cell Survival; Cell viability; Exercise; Extracellular Space - metabolism; Hand Strength; Humanities and Social Sciences; Male; Maturation; Mice; Mice, Inbred C57BL; MicroRNAs - genetics; Microtubule-associated protein 2; miRNA; Motor Activity; multidisciplinary; Neural stem cells; Neurons - cytology; Particle Size; Phosphatidylinositol 3-Kinases - metabolism; Phosphorylation; Physical activity; Physical Conditioning, Animal - physiology; Physical fitness; Physical training; Progenitor cells; Proto-Oncogene Proteins c-akt - metabolism; Running; Science; Science (multidisciplinary); Size distribution; Stem cell transplantation; Stem cells; Tubulin
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-020-60930-6

Physical activity has profound effects on neuronal progenitor cell growth, differentiation, and integration, but the mechanism for these effects is still ambiguous. Using a mouse model, we investigated the effects of two weeks of treadmill running on the dynamics of the size distribution and miRNA profiles of serum extracellular derivatives (EDs) using particle-sizing analysis and small RNA sequencing. We found that an increased average diameter of EDs in the running group compared with the sedentary group (p