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Neural maturation enhanced by exercise-induced extracellular derivatives
Physical activity has profound effects on neuronal progenitor cell growth, differentiation, and integration, but the mechanism for these effects is still ambiguous. Using a mouse model, we investigated the effects of two weeks of treadmill running on the dynamics of the size distribution and miRNA p...
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| Published in: | Scientific reports 2020-03, Vol.10 (1), p.3893-3893, Article 3893 |
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| creator | Moon, Hyo Youl Yoon, Kyeong Jin Lee, Won Sang Cho, Hae-Sung Kim, Do-Yeon Kim, Ji-Seok |
| description | Physical activity has profound effects on neuronal progenitor cell growth, differentiation, and integration, but the mechanism for these effects is still ambiguous. Using a mouse model, we investigated the effects of two weeks of treadmill running on the dynamics of the size distribution and miRNA profiles of serum extracellular derivatives (EDs) using particle-sizing analysis and small RNA sequencing. We found that an increased average diameter of EDs in the running group compared with the sedentary group (p |
| doi_str_mv | 10.1038/s41598-020-60930-6 |
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Using a mouse model, we investigated the effects of two weeks of treadmill running on the dynamics of the size distribution and miRNA profiles of serum extracellular derivatives (EDs) using particle-sizing analysis and small RNA sequencing. We found that an increased average diameter of EDs in the running group compared with the sedentary group (p < 0.05), and 16 miRNAs were significantly altered (p < 0.05) in the running group. Furthermore, functional annotation analysis of differentially expressed miRNA-predicted target genes showed that many of these target genes are involved in the PI3K-Akt pathway. Exercise-induced serum EDs increased Neuro2A cell viability and Akt phosphorylation. We also found that expression levels of neuronal maturation markers such as Microtubule-Associated Protein 2 (MAP2ab) and Neuronal nuclei (NeuN) were increased (p < 0.05, respectively), and that inhibition of the PI3K-Akt pathway by LY294002 pre-treatment ameliorated their expression in Neuro2A cells. Finally, the administration of exercise-induced EDs for 3 days increased the Histone 3 phosphorylation and β-III tubulin expression in Ink/Arf null neural stem cells and progenitors (NSPCs) under each proliferation and differentiation condition. These results suggest that exercise-induced circulating EDs may mediate neuronal maturation during exercise.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-60930-6</identifier><identifier>PMID: 32127592</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>1-Phosphatidylinositol 3-kinase ; 13 ; 13/21 ; 13/95 ; 38 ; 38/77 ; 38/91 ; 631/443/376 ; 64/60 ; 692/4017 ; AKT protein ; Animals ; Brain - cytology ; Brain - growth & development ; Brain - physiology ; Cell differentiation ; Cell Line ; Cell Proliferation ; Cell Survival ; Cell viability ; Exercise ; Extracellular Space - metabolism ; Hand Strength ; Humanities and Social Sciences ; Male ; Maturation ; Mice ; Mice, Inbred C57BL ; MicroRNAs - genetics ; Microtubule-associated protein 2 ; miRNA ; Motor Activity ; multidisciplinary ; Neural stem cells ; Neurons - cytology ; Particle Size ; Phosphatidylinositol 3-Kinases - metabolism ; Phosphorylation ; Physical activity ; Physical Conditioning, Animal - physiology ; Physical fitness ; Physical training ; Progenitor cells ; Proto-Oncogene Proteins c-akt - metabolism ; Running ; Science ; Science (multidisciplinary) ; Size distribution ; Stem cell transplantation ; Stem cells ; Tubulin</subject><ispartof>Scientific reports, 2020-03, Vol.10 (1), p.3893-3893, Article 3893</ispartof><rights>The Author(s) 2020</rights><rights>This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c511t-a25c02644e3ad214600c01afc7ae712a300bc6bbddf41030fe8dbe228a823cd33</citedby><cites>FETCH-LOGICAL-c511t-a25c02644e3ad214600c01afc7ae712a300bc6bbddf41030fe8dbe228a823cd33</cites><orcidid>0000-0001-8207-1301 ; 0000-0003-2200-7396 ; 0000-0002-4849-7808</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2370451878/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2370451878?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,25731,27901,27902,36989,36990,44566,53766,53768,74869</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32127592$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moon, Hyo Youl</creatorcontrib><creatorcontrib>Yoon, Kyeong Jin</creatorcontrib><creatorcontrib>Lee, Won Sang</creatorcontrib><creatorcontrib>Cho, Hae-Sung</creatorcontrib><creatorcontrib>Kim, Do-Yeon</creatorcontrib><creatorcontrib>Kim, Ji-Seok</creatorcontrib><title>Neural maturation enhanced by exercise-induced extracellular derivatives</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Physical activity has profound effects on neuronal progenitor cell growth, differentiation, and integration, but the mechanism for these effects is still ambiguous. Using a mouse model, we investigated the effects of two weeks of treadmill running on the dynamics of the size distribution and miRNA profiles of serum extracellular derivatives (EDs) using particle-sizing analysis and small RNA sequencing. We found that an increased average diameter of EDs in the running group compared with the sedentary group (p < 0.05), and 16 miRNAs were significantly altered (p < 0.05) in the running group. Furthermore, functional annotation analysis of differentially expressed miRNA-predicted target genes showed that many of these target genes are involved in the PI3K-Akt pathway. Exercise-induced serum EDs increased Neuro2A cell viability and Akt phosphorylation. We also found that expression levels of neuronal maturation markers such as Microtubule-Associated Protein 2 (MAP2ab) and Neuronal nuclei (NeuN) were increased (p < 0.05, respectively), and that inhibition of the PI3K-Akt pathway by LY294002 pre-treatment ameliorated their expression in Neuro2A cells. Finally, the administration of exercise-induced EDs for 3 days increased the Histone 3 phosphorylation and β-III tubulin expression in Ink/Arf null neural stem cells and progenitors (NSPCs) under each proliferation and differentiation condition. These results suggest that exercise-induced circulating EDs may mediate neuronal maturation during exercise.</description><subject>1-Phosphatidylinositol 3-kinase</subject><subject>13</subject><subject>13/21</subject><subject>13/95</subject><subject>38</subject><subject>38/77</subject><subject>38/91</subject><subject>631/443/376</subject><subject>64/60</subject><subject>692/4017</subject><subject>AKT protein</subject><subject>Animals</subject><subject>Brain - cytology</subject><subject>Brain - growth & development</subject><subject>Brain - physiology</subject><subject>Cell differentiation</subject><subject>Cell Line</subject><subject>Cell Proliferation</subject><subject>Cell Survival</subject><subject>Cell viability</subject><subject>Exercise</subject><subject>Extracellular Space - metabolism</subject><subject>Hand Strength</subject><subject>Humanities and Social Sciences</subject><subject>Male</subject><subject>Maturation</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>MicroRNAs - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moon, Hyo Youl</au><au>Yoon, Kyeong Jin</au><au>Lee, Won Sang</au><au>Cho, Hae-Sung</au><au>Kim, Do-Yeon</au><au>Kim, Ji-Seok</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neural maturation enhanced by exercise-induced extracellular derivatives</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2020-03-03</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>3893</spage><epage>3893</epage><pages>3893-3893</pages><artnum>3893</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Physical activity has profound effects on neuronal progenitor cell growth, differentiation, and integration, but the mechanism for these effects is still ambiguous. Using a mouse model, we investigated the effects of two weeks of treadmill running on the dynamics of the size distribution and miRNA profiles of serum extracellular derivatives (EDs) using particle-sizing analysis and small RNA sequencing. We found that an increased average diameter of EDs in the running group compared with the sedentary group (p < 0.05), and 16 miRNAs were significantly altered (p < 0.05) in the running group. Furthermore, functional annotation analysis of differentially expressed miRNA-predicted target genes showed that many of these target genes are involved in the PI3K-Akt pathway. Exercise-induced serum EDs increased Neuro2A cell viability and Akt phosphorylation. We also found that expression levels of neuronal maturation markers such as Microtubule-Associated Protein 2 (MAP2ab) and Neuronal nuclei (NeuN) were increased (p < 0.05, respectively), and that inhibition of the PI3K-Akt pathway by LY294002 pre-treatment ameliorated their expression in Neuro2A cells. Finally, the administration of exercise-induced EDs for 3 days increased the Histone 3 phosphorylation and β-III tubulin expression in Ink/Arf null neural stem cells and progenitors (NSPCs) under each proliferation and differentiation condition. These results suggest that exercise-induced circulating EDs may mediate neuronal maturation during exercise.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32127592</pmid><doi>10.1038/s41598-020-60930-6</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-8207-1301</orcidid><orcidid>https://orcid.org/0000-0003-2200-7396</orcidid><orcidid>https://orcid.org/0000-0002-4849-7808</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 1-Phosphatidylinositol 3-kinase 13 13/21 13/95 38 38/77 38/91 631/443/376 64/60 692/4017 AKT protein Animals Brain - cytology Brain - growth & development Brain - physiology Cell differentiation Cell Line Cell Proliferation Cell Survival Cell viability Exercise Extracellular Space - metabolism Hand Strength Humanities and Social Sciences Male Maturation Mice Mice, Inbred C57BL MicroRNAs - genetics Microtubule-associated protein 2 miRNA Motor Activity multidisciplinary Neural stem cells Neurons - cytology Particle Size Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Physical activity Physical Conditioning, Animal - physiology Physical fitness Physical training Progenitor cells Proto-Oncogene Proteins c-akt - metabolism Running Science Science (multidisciplinary) Size distribution Stem cell transplantation Stem cells Tubulin |
| title | Neural maturation enhanced by exercise-induced extracellular derivatives |
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