Cost-Effectiveness Analysis of Baseline Testing for Resistance-Associated Polymorphisms to Optimize Treatment Outcome in Genotype 1 Noncirrhotic Treatment-Naïve Patients With Chronic Hepatitis C Virus

Direct-acting antivirals containing nonstructural protein 5A (NS5A) inhibitors administered over 8 to 12 weeks are effective in ∼95% of patients with hepatitis C virus. Nevertheless, patients resistant to NS5A inhibitors have lower cure rates over 8 weeks (

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Bibliographic Details
Published in:Value in health 2020-02, Vol.23 (2), p.180-190
Main Authors: Fawsitt, Christopher G., Vickerman, Peter, Cooke, Graham S., Barnes, Eleanor, Ball, Jonathan, Brainard, Diana, Burgess, Gary, Dillon, John, Foster, Graham, Gore, Charles, Guha, Neil, Halford, Rachel, Whitby, Kevin, Holmes, Chris, Howe, Anita, Hudson, Emma, Hutchinson, Sharon, Irving, William, Khakoo, Salim, Klenerman, Paul, Martin, Natasha, Massetto, Benedetta, Mbisa, Tamyo, McHutchison, John, McKeating, Jane, McLauchlan, John, Miners, Alec, Murray, Andrea, Shaw, Peter, Simmonds, Peter, Spencer, Chris, Thomson, Emma, Zitzmann, Nicole, Welton, Nicky J.
Format: Article
Language:English
Subjects:
Adult
Antiviral agents
Antiviral Agents - adverse effects
Antiviral Agents - economics
Antiviral Agents - therapeutic use
Antiviral drugs
baseline testing
Cost analysis
Cost-Benefit Analysis
cost-effectiveness
Cure
Decision Support Techniques
Decision Trees
Drug Costs
Drug prices
Drug Resistance, Viral - genetics
Female
Genotype
Genotype & phenotype
Genotypes
Health services
Hepacivirus - drug effects
Hepacivirus - genetics
Hepatitis
Hepatitis C
hepatitis C virus
Hepatitis C, Chronic - diagnosis
Hepatitis C, Chronic - drug therapy
Hepatitis C, Chronic - economics
Hepatitis C, Chronic - virology
Humans
Male
Markov Chains
Models, Economic
Molecular Diagnostic Techniques - economics
Molecular Targeted Therapy - economics
Polymorphism
Polymorphism, Genetic
Predictive Value of Tests
Prices
Quality-Adjusted Life Years
Resistance
resistance-associated polymorphisms
State Medicine - economics
Time Factors
Treatment Outcome
United Kingdom
Viral Nonstructural Proteins - antagonists & inhibitors
Viral Nonstructural Proteins - genetics
Viral Nonstructural Proteins - metabolism
Willingness to pay
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Description
Summary:Direct-acting antivirals containing nonstructural protein 5A (NS5A) inhibitors administered over 8 to 12 weeks are effective in ∼95% of patients with hepatitis C virus. Nevertheless, patients resistant to NS5A inhibitors have lower cure rates over 8 weeks (
ISSN:1098-3015
1524-4733
DOI:10.1016/j.jval.2019.08.012