Gastroprotective Activity of the Total Flavones from Abelmoschus manihot (L.) Medic Flowers

Background. Abelmoschus manihot (L.) Medic flower is a medicinal plant for the treatment of diseases in China. The present study was carried out to scientifically validate the gastroprotective activity and clarify the possible mechanism of the total flavones from Abelmoschus manihot (L.) Medic flowe...

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Published in:Evidence-based complementary and alternative medicine 2020, Vol.2020 (2020), p.1-9
Main Authors: Song, Bi-Wei, Chu, Zhao-Xing, Fu, Zai-Lin, Zhang, Jun
Format: Article
Language:English
Subjects:
Abelmoschus manihot
Acids
Alcohol
Alternative medicine
Aluminum
BAX protein
Bcl-2 protein
Bioengineering
Bioflavonoids
Ethanol
Evidence-based medicine
Flavones
Flavonoids
Flowers
Gastrointestinal agents
Glutathione
Herbal medicine
Homeopathy
Inflammation
Laboratory animals
Malondialdehyde
Materia medica and therapeutics
Medical research
Medicinal plants
Medicine, Botanic
Medicine, Herbal
NF-κB protein
Omeprazole
Oral administration
Pharmaceutical sciences
Proteins
Sodium
Superoxide
Superoxide dismutase
Therapeutics
Tumor necrosis factor-α
Ulcers
Western blotting
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Zhang, Jun
description Background. Abelmoschus manihot (L.) Medic flower is a medicinal plant for the treatment of diseases in China. The present study was carried out to scientifically validate the gastroprotective activity and clarify the possible mechanism of the total flavones from Abelmoschus manihot (L.) Medic flowers (TFA). Methods. Gastric ulcer was induced in mice by oral administration of ethanol. The gastroprotective activity of TFA was evaluated by the gastric ulcer index and histological examinations. The gastric tissue was collected in the form of homogenate. The level of malondialdehyde (MDA) and glutathione (GSH), the activity of superoxide dismutase (SOD), and protein content were measured. Western blotting for the expression of Bax, Bcl-2, TNF-α, and NF-κB(p65) was also carried out. The effect of TFA was compared with that of standard antiulcer drug omeprazole (100 mg/kg). Results. This gastroprotective effect of TFA could be attributed to the increase in the activity of SOD and GSH and decrease in the levels of MDA and also decrease in the levels of Bax, TNF-α, and NF-κB(p65) expressions and increase in the Bcl-2 expression level. Conclusion. The findings of this study demonstrated that TFA could significantly attenuate ethanol-induced gastric injury via antioxidative, anti-inflammatory, and antiapoptotic effects.
doi_str_mv 10.1155/2020/6584945
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Medic Flowers</title><source>Wiley Online Library Open Access</source><source>Publicly Available Content Database</source><creator>Song, Bi-Wei ; Chu, Zhao-Xing ; Fu, Zai-Lin ; Zhang, Jun</creator><contributor>Lenon, George B. ; George B Lenon</contributor><creatorcontrib>Song, Bi-Wei ; Chu, Zhao-Xing ; Fu, Zai-Lin ; Zhang, Jun ; Lenon, George B. ; George B Lenon</creatorcontrib><description>Background. Abelmoschus manihot (L.) Medic flower is a medicinal plant for the treatment of diseases in China. The present study was carried out to scientifically validate the gastroprotective activity and clarify the possible mechanism of the total flavones from Abelmoschus manihot (L.) Medic flowers (TFA). Methods. Gastric ulcer was induced in mice by oral administration of ethanol. The gastroprotective activity of TFA was evaluated by the gastric ulcer index and histological examinations. The gastric tissue was collected in the form of homogenate. The level of malondialdehyde (MDA) and glutathione (GSH), the activity of superoxide dismutase (SOD), and protein content were measured. Western blotting for the expression of Bax, Bcl-2, TNF-α, and NF-κB(p65) was also carried out. The effect of TFA was compared with that of standard antiulcer drug omeprazole (100 mg/kg). Results. This gastroprotective effect of TFA could be attributed to the increase in the activity of SOD and GSH and decrease in the levels of MDA and also decrease in the levels of Bax, TNF-α, and NF-κB(p65) expressions and increase in the Bcl-2 expression level. Conclusion. The findings of this study demonstrated that TFA could significantly attenuate ethanol-induced gastric injury via antioxidative, anti-inflammatory, and antiapoptotic effects.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2020/6584945</identifier><identifier>PMID: 32184895</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Abelmoschus manihot ; Acids ; Alcohol ; Alternative medicine ; Aluminum ; BAX protein ; Bcl-2 protein ; Bioengineering ; Bioflavonoids ; Ethanol ; Evidence-based medicine ; Flavones ; Flavonoids ; Flowers ; Gastrointestinal agents ; Glutathione ; Herbal medicine ; Homeopathy ; Inflammation ; Laboratory animals ; Malondialdehyde ; Materia medica and therapeutics ; Medical research ; Medicinal plants ; Medicine, Botanic ; Medicine, Herbal ; NF-κB protein ; Omeprazole ; Oral administration ; Pharmaceutical sciences ; Proteins ; Sodium ; Superoxide ; Superoxide dismutase ; Therapeutics ; Tumor necrosis factor-α ; Ulcers ; Western blotting</subject><ispartof>Evidence-based complementary and alternative medicine, 2020, Vol.2020 (2020), p.1-9</ispartof><rights>Copyright © 2020 Jun Zhang et al.</rights><rights>COPYRIGHT 2020 John Wiley &amp; Sons, Inc.</rights><rights>Copyright © 2020 Jun Zhang et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 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Medic Flowers</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description>Background. Abelmoschus manihot (L.) Medic flower is a medicinal plant for the treatment of diseases in China. The present study was carried out to scientifically validate the gastroprotective activity and clarify the possible mechanism of the total flavones from Abelmoschus manihot (L.) Medic flowers (TFA). Methods. Gastric ulcer was induced in mice by oral administration of ethanol. The gastroprotective activity of TFA was evaluated by the gastric ulcer index and histological examinations. The gastric tissue was collected in the form of homogenate. The level of malondialdehyde (MDA) and glutathione (GSH), the activity of superoxide dismutase (SOD), and protein content were measured. Western blotting for the expression of Bax, Bcl-2, TNF-α, and NF-κB(p65) was also carried out. The effect of TFA was compared with that of standard antiulcer drug omeprazole (100 mg/kg). Results. This gastroprotective effect of TFA could be attributed to the increase in the activity of SOD and GSH and decrease in the levels of MDA and also decrease in the levels of Bax, TNF-α, and NF-κB(p65) expressions and increase in the Bcl-2 expression level. Conclusion. 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Medic Flowers</atitle><jtitle>Evidence-based complementary and alternative medicine</jtitle><addtitle>Evid Based Complement Alternat Med</addtitle><date>2020</date><risdate>2020</risdate><volume>2020</volume><issue>2020</issue><spage>1</spage><epage>9</epage><pages>1-9</pages><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract>Background. Abelmoschus manihot (L.) Medic flower is a medicinal plant for the treatment of diseases in China. The present study was carried out to scientifically validate the gastroprotective activity and clarify the possible mechanism of the total flavones from Abelmoschus manihot (L.) Medic flowers (TFA). Methods. Gastric ulcer was induced in mice by oral administration of ethanol. The gastroprotective activity of TFA was evaluated by the gastric ulcer index and histological examinations. The gastric tissue was collected in the form of homogenate. The level of malondialdehyde (MDA) and glutathione (GSH), the activity of superoxide dismutase (SOD), and protein content were measured. Western blotting for the expression of Bax, Bcl-2, TNF-α, and NF-κB(p65) was also carried out. The effect of TFA was compared with that of standard antiulcer drug omeprazole (100 mg/kg). Results. This gastroprotective effect of TFA could be attributed to the increase in the activity of SOD and GSH and decrease in the levels of MDA and also decrease in the levels of Bax, TNF-α, and NF-κB(p65) expressions and increase in the Bcl-2 expression level. Conclusion. The findings of this study demonstrated that TFA could significantly attenuate ethanol-induced gastric injury via antioxidative, anti-inflammatory, and antiapoptotic effects.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>32184895</pmid><doi>10.1155/2020/6584945</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-9295-0171</orcidid><orcidid>https://orcid.org/0000-0002-1864-271X</orcidid><oa>free_for_read</oa></addata></record>
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subjects Abelmoschus manihot
Acids
Alcohol
Alternative medicine
Aluminum
BAX protein
Bcl-2 protein
Bioengineering
Bioflavonoids
Ethanol
Evidence-based medicine
Flavones
Flavonoids
Flowers
Gastrointestinal agents
Glutathione
Herbal medicine
Homeopathy
Inflammation
Laboratory animals
Malondialdehyde
Materia medica and therapeutics
Medical research
Medicinal plants
Medicine, Botanic
Medicine, Herbal
NF-κB protein
Omeprazole
Oral administration
Pharmaceutical sciences
Proteins
Sodium
Superoxide
Superoxide dismutase
Therapeutics
Tumor necrosis factor-α
Ulcers
Western blotting
title Gastroprotective Activity of the Total Flavones from Abelmoschus manihot (L.) Medic Flowers
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