The role of IL-22 in intestinal health and disease

The cytokine interleukin-22 (IL-22) is a critical regulator of epithelial homeostasis. It has been implicated in multiple aspects of epithelial barrier function, including regulation of epithelial cell growth and permeability, production of mucus and antimicrobial proteins (AMPs), and complement pro...

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Bibliographic Details
Published in:The Journal of experimental medicine 2020-03, Vol.217 (3), p.e20192195-e20192195
Main Authors: Keir, Mary, Yi, Tangsheng, Lu, Timothy, Ghilardi, Nico
Format: Article
Language:English
Subjects:
Animals
Cytokines Focus
Epithelial Cells - metabolism
Graft vs Host Disease - metabolism
Humans
Inflammatory Bowel Diseases - metabolism
Interleukin-22
Interleukins - metabolism
Intestinal Mucosa - metabolism
Intestines - pathology
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Summary:The cytokine interleukin-22 (IL-22) is a critical regulator of epithelial homeostasis. It has been implicated in multiple aspects of epithelial barrier function, including regulation of epithelial cell growth and permeability, production of mucus and antimicrobial proteins (AMPs), and complement production. In this review, we focus specifically on the role of IL-22 in the intestinal epithelium. We summarize recent advances in our understanding of how IL-22 regulates homeostasis and host defense, and we discuss the IL-22 pathway as a therapeutic target in diseases of the intestine, including inflammatory bowel disease (IBD), graft-versus-host disease (GVHD), and cancer.
ISSN:0022-1007
1540-9538
DOI:10.1084/jem.20192195