The Changing Epidemiology of Hepatocellular Carcinoma : Experience of a Single Center

Aims. To analyze the main etiological factors and some clinical features of patients with hepatocellular carcinoma (HCC) at diagnosis and to compare them with those we described ten years ago. Materials and Methods. We compared two groups of patients with HCC, Group 1 consisting of 132 patients (82 ...

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Published in:BioMed research international 2020, Vol.2020 (2020), p.1-9
Main Authors: Brancatelli, Giuseppe, Montalto, Giuseppe, Soresi, Maurizio, Licata, Anna, Minissale, Maria Giovanna, Li Cavoli, Tancredi Vincenzo, Galia, Massimo, Pipitone, Elisa, Amodeo, Simona, Zerbo, Maddalena, Giannitrapani, Lydia, Schiavone, Cosima
Format: Article
Language:English
Subjects:
Age
Aged
Alcohol
alpha-Fetoproteins - metabolism
Carcinoma, Hepatocellular - epidemiology
Carcinoma, Hepatocellular - etiology
Carcinoma, Hepatocellular - metabolism
Carcinoma, Hepatocellular - pathology
Development and progression
Diabetes
Diagnosis
Diagnostic systems
Epidemiology
Etiology
Female
Glycoproteins
Hepatitis
Hepatitis B - complications
Hepatitis C - complications
Hepatitis C virus
Hepatocellular carcinoma
Hepatoma
Humans
Hypertension
Liver
Liver cancer
Liver cirrhosis
Liver diseases
Liver Neoplasms - epidemiology
Liver Neoplasms - etiology
Liver Neoplasms - metabolism
Liver Neoplasms - pathology
Male
Medical prognosis
Metabolism
Neoplasm Staging - methods
Noncitizens
Patients
Risk Factors
Serum levels
Tumor staging
Tumors
Viral infections
Viruses
α-Fetoprotein
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Summary:Aims. To analyze the main etiological factors and some clinical features of patients with hepatocellular carcinoma (HCC) at diagnosis and to compare them with those we described ten years ago. Materials and Methods. We compared two groups of patients with HCC, Group 1 consisting of 132 patients (82 M, 50 F) diagnosed in the 2003–2008 period and Group 2 including 119 patients (82 M, 37 F) diagnosed in the 2013–2018 period. For all patients, age, sex, viral markers, alcohol consumption, serum alpha-fetoprotein (AFP) levels, and the main liver function parameters were recorded. The diagnosis of HCC was based on AASLD, EASL guidelines. The staging was classified according to the “Barcelona Clinic Liver Cancer staging system” (BCLC). Results. Mean age was 69.0 ± 8 years in Group 1 and 71.0 ± 9 in Group 2 (P
ISSN:2314-6133
2314-6141
DOI:10.1155/2020/5309307