Loading…
Molecular identification of Brucella species and biovars associated with animal and human infection in Iran
Brucellosis is a costly contagious disease of human, domestic and wild animals. It is a serious health problem in Iran causing significant economic losses therefore, control approaches to prevent its spread are of great importance. In Iran, the species and biovars of virulent Brucella species are st...
Saved in:
Published in: | Veterinary research forum 2019-01, Vol.10 (4), p.315-321 |
---|---|
Main Authors: | , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Summary: | Brucellosis is a costly contagious disease of human, domestic and wild animals. It is a serious health problem in Iran causing significant economic losses therefore, control approaches to prevent its spread are of great importance. In Iran, the species and biovars of virulent
Brucella
species are still under-reported due to the inadequate diagnostic protocols and insufficient laboratory facilities. The objective of this study was to characterize
Brucella
isolates obtained from passive animal and human surveillance in Iran from 2011 to 2018 in order to understand the current epidemiological situation of the disease. A total of 419 samples (milk, blood, cerebrospinal fluid, abomasum content and aborted fetus tissues) were collected from 65 cases/case series (human and animals) and examined bacteriologically. The initially identified
Brucella
isolates were further characterized using phenotypic and molecular approaches. All recovered isolates were either
B. abortus
or
B. melitensis
. The infection in sheep appeared to be exclusively associated with
B. melitensis,
but both
B. abortus
and
B. melitensis
were common in bovine samples. Samples from one sheep and one goat were confirmed to be infected by the
B. melitensis
vaccine strain Rev1. In spite of
B. abortus
burden in animals (14 cases in cattle and camel), brucellosis in human was predominantly associated with
B. melitensis
(15 cases). The results confirmed that
B. melitensis
 biovar 1 and
B. abortus
biovar 3 remain the most prevalent biovars in Iran. This report builds a picture of the significance of different
Brucella
species in different hosts in Iran and provides applicable information for the healthcare professionals about the public health risks of brucellosis and relevant preventive strategies. |
---|---|
ISSN: | 2008-8140 2322-3618 |
DOI: | 10.30466/vrf.2018.89680.2171 |