The effects of whortleberry on ischemia reperfusion-induced myocardial injury in rats

• Published in: Türk göğüs kalp damar cerrahisi dergisi 2020-01, Vol.28 (1), p.63-69
• Main Authors: Karakişi, Sedat Ozan, Hemşinli, Doğuş, Ergene, Şaban, Mercantepe, Tolga, Tümkaya, Levent, Yılmaz, Adnan
• Format: Article
• Language: English
• Subjects: Original
• ISSN: 1301-5680; 2149-8156
• DOI: 10.5606/tgkdc.dergisi.2020.18389

The aim of this study was to investigate the potential protective effect of whortleberry by examining the effects on heart tissue at the molecular level of ischemia-reperfusion injury caused by surgical repair of a ruptured abdominal aortic aneurysm. Between May 2018 and February 2019, a total of 32 male Sprague-Dawley rats were randomly assigned into control, sham (ischemia-reperfusion+glycerol), ischemia-reperfusion, and ischemia-reperfusion+whortleberry groups. Hypovolemic shock was applied to the rats in the ischemia-reperfusion groups for one hour. The abdominal aorta was explored following midline laparotomy and atraumatic microvascular clamps were applied from the infrarenal level. Following one-hour ischemia, the clamps were removed, and reperfusion was established for two hours. In the sham group, intraperitoneal glycerol once daily was applied five days before surgery. In the whortleberry group, whortleberry treatment was administered via the intraperitoneal route five days before ischemia-reperfusion. The ischemia-reperfusion group exhibited a decrease in the glutathione levels and an increase in the malondialdehyde levels (p