The effects of whortleberry on ischemia reperfusion-induced myocardial injury in rats

The aim of this study was to investigate the potential protective effect of whortleberry by examining the effects on heart tissue at the molecular level of ischemia-reperfusion injury caused by surgical repair of a ruptured abdominal aortic aneurysm. Between May 2018 and February 2019, a total of 32...

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Published in:Türk göğüs kalp damar cerrahisi dergisi 2020-01, Vol.28 (1), p.63-69
Main Authors: Karakişi, Sedat Ozan, Hemşinli, Doğuş, Ergene, Şaban, Mercantepe, Tolga, Tümkaya, Levent, Yılmaz, Adnan
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container_title Türk göğüs kalp damar cerrahisi dergisi
container_volume 28
creator Karakişi, Sedat Ozan
Hemşinli, Doğuş
Ergene, Şaban
Mercantepe, Tolga
Tümkaya, Levent
Yılmaz, Adnan
description The aim of this study was to investigate the potential protective effect of whortleberry by examining the effects on heart tissue at the molecular level of ischemia-reperfusion injury caused by surgical repair of a ruptured abdominal aortic aneurysm. Between May 2018 and February 2019, a total of 32 male Sprague-Dawley rats were randomly assigned into control, sham (ischemia-reperfusion+glycerol), ischemia-reperfusion, and ischemia-reperfusion+whortleberry groups. Hypovolemic shock was applied to the rats in the ischemia-reperfusion groups for one hour. The abdominal aorta was explored following midline laparotomy and atraumatic microvascular clamps were applied from the infrarenal level. Following one-hour ischemia, the clamps were removed, and reperfusion was established for two hours. In the sham group, intraperitoneal glycerol once daily was applied five days before surgery. In the whortleberry group, whortleberry treatment was administered via the intraperitoneal route five days before ischemia-reperfusion. The ischemia-reperfusion group exhibited a decrease in the glutathione levels and an increase in the malondialdehyde levels (p
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We also observed an increase in the caspase-3 positivity in cardiac myofibrils (p&lt;0.01). Whortleberry administration lowered both malondialdehyde levels and numerical density of caspase-3 positive cardiac myofibrils, while increasing the heart tissue glutathione levels, compared to the ischemia-reperfusion alone group (p&lt;0.01, p=0.011, and p=0.011, respectively). 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title The effects of whortleberry on ischemia reperfusion-induced myocardial injury in rats
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