Parapapillary atrophy and changes in the optic nerve head and posterior pole in high myopia

• Published in: Scientific reports 2020-03, Vol.10 (1), p.4607-4607, Article 4607
• Main Authors: Sung, Mi Sun, Heo, Hwan, Piao, Helong, Guo, Yue, Park, Sang Woo
• Format: Article
• Language: English
• Subjects: 692/698; 692/699/3161; Adult; Atrophy; Biomarkers; Bruch Membrane - pathology; Choroid - metabolism; Choroid - pathology; Eye; Female; Glaucoma; Humanities and Social Sciences; Humans; Male; multidisciplinary; Myopia; Myopia - diagnostic imaging; Myopia - etiology; Myopia - metabolism; Myopia - pathology; Optic Atrophy - diagnostic imaging; Optic Atrophy - etiology; Optic Atrophy - pathology; Optic Disk - pathology; Optic nerve; Optics; Science; Science (multidisciplinary); Young Adult
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-020-61485-2

We investigated the relationship between microstructure of β-parapapillary atrophy (β-PPA) and morphologic features of optic nerve head (ONH) and posterior pole in highly myopic eyes. Eighty-nine highly myopic eyes were included in this study. Bruch’s membrane opening (BMO) area, lamina cribrosa (LC) thickness, anterior laminar depth, peripapillary and subfoveal choroidal thickness (CT), macular Bruch’s membrane (BM) length, and width of β-PPA with and without Bruch’s membrane (PPA +BM and PPA −BM ) were evaluated. The mean age and axial length of the included subjects were 26.88 ± 2.44 years and 27.03 ± 0.88 mm, respectively. The width of PPA −BM was larger with increasing BMO area ( P  = 0.001), whereas the BMO area was not associated with the width of PPA +BM . The large PPA +BM was significantly related to a thinner LC ( P  = 0.003), deeper anterior lamina surface ( P