Residential Radon and Histological Types of Lung Cancer: A Meta-Analysis of Case‒Control Studies

Epidemiological studies on residential radon exposure and the risk of histological types of lung cancer have yielded inconsistent results. We conducted a meta-analysis on this topic and updated previous related meta-analyses. We searched the databases of Cochrane Library, Embase, PubMed, Web of Scie...

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Bibliographic Details
Published in:International journal of environmental research and public health 2020-02, Vol.17 (4), p.1457
Main Authors: Li, Cong, Wang, Chunhong, Yu, Jun, Fan, Yongsheng, Liu, Duanya, Zhou, Wenshan, Shi, Tingming
Format: Article
Language:English
Subjects:
Adenocarcinoma
Brain cancer
Cancer therapies
Confidence intervals
Epidemiology
Exposure
Health risks
Lung cancer
Lung carcinoma
Medical prognosis
Meta-analysis
Population
Radon
Risk
Smoking
Squamous cell carcinoma
Studies
Subgroups
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Summary:Epidemiological studies on residential radon exposure and the risk of histological types of lung cancer have yielded inconsistent results. We conducted a meta-analysis on this topic and updated previous related meta-analyses. We searched the databases of Cochrane Library, Embase, PubMed, Web of Science and Chinese National Knowledge Infrastructure for papers published up to 13 November 2018. The pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using fixed and random effects models. Subgroup and dose‒response analyses were also conducted. This study was registered with PROSPERO (No. CRD42019127761). A total of 28 studies, which included 13,748 lung cancer cases and 23,112 controls, were used for this meta-analysis. The pooled OR indicated that the highest residential radon exposure was significantly associated with an increased risk of lung cancer (OR = 1.48, 95% CI = 1.26-1.73). All histological types of lung cancer were associated with residential radon. Strongest association with small-cell lung carcinoma (OR = 2.03, 95% CI = 1.52-2.71) was found, followed by adenocarcinoma (OR = 1.58, 95% CI = 1.31-1.91), other histological types (OR = 1.54, 95% CI = 1.11-2.15) and squamous cell carcinoma (OR = 1.43, 95% CI = 1.18-1.74). With increasing residential radon levels per 100 Bq/m , the risk of lung cancer, small-cell lung carcinoma and adenocarcinoma increased by 11%, 19% and 13%, respectively. This meta-analysis provides new evidence for a potential relationship between residential radon and all histological types of lung cancer.
ISSN:1660-4601
1661-7827
1660-4601
DOI:10.3390/ijerph17041457