Reply to Turnbull et al. and to Hulme et al

Breuer et al discuss the study by Hulme et al who presented infection prevalence data from a 6-year BAL surveillance program The Study of Host Immunity and Early Lung Disease in Cystic Fibrosis (SHIELD CF). Hulme et al presented the prevalence rates of Aspergillus infections in patients with CF vary...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2020-03, Vol.201 (6), p.750-752
Main Authors: Breuer, Oded, Schultz, Andre, Turkovic, Lidija, de Klerk, Nicholas, Keil, Anthony D, Brennan, Siobhain, Harrison, Joanne, Robertson, Colin, Robinson, Philip J, Sly, Peter D, Ranganathan, Sarath, Stick, Stephen M, Caudri, Daan
Format: Article
Language:English
Subjects:
Bacterial infections
Correspondence
Cystic fibrosis
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Summary:Breuer et al discuss the study by Hulme et al who presented infection prevalence data from a 6-year BAL surveillance program The Study of Host Immunity and Early Lung Disease in Cystic Fibrosis (SHIELD CF). Hulme et al presented the prevalence rates of Aspergillus infections in patients with CF vary widely among studies, mainly because of differences in the culturing methods and sample-processing techniques used, but also because of the different routines used for nebulized antibacterial therapies. Furthermore, bacterial infections may inhibit culture growth of Aspergillus species, which would also influence the reported prevalence. The cohort showed an overall 40% incidence of aspergillus species infection in the first 6 years of life, which is similar to what has been reported in other studies.
ISSN:1073-449X
1535-4970
DOI:10.1164/rccm.201911-2213LE