Diagnosing coeliac disease in the elderly: a United Kingdom cohort study

To assess the outcomes for an elderly population with coeliac disease and to compare with younger adults with CD. Coeliac disease in the elderly has been underdiagnosed due to the heterogeneity of presentation as well as lack of physicians' awareness of CD in this population. However, the benef...

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Published in:Gastroenterology and hepatology from bed to bench 2020, Vol.13 (1), p.37-43
Main Authors: Shiha, Mohamed G, Marks, Lauren J, Sanders, David S
Format: Article
Language:English
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Summary:To assess the outcomes for an elderly population with coeliac disease and to compare with younger adults with CD. Coeliac disease in the elderly has been underdiagnosed due to the heterogeneity of presentation as well as lack of physicians' awareness of CD in this population. However, the benefits of diagnosing CD in the elderly may be contentious. Newly diagnosed CD patients were prospectively recruited from the Coeliac Specialist Clinic at the Royal Hallamshire Hospital, Sheffield, between 2008 and 2017. All patients had villous atrophy (VA) on biopsy with positive coeliac serology. Additionally, the patients were retrospectively recruited from 1990 to 2008 to determine the trend in elderly CD diagnostic frequency over time. A total of 1605 patients with CD were recruited (n=644 prospectively, n=961 retrospectively). Of these, 208 patients (13.0%) were diagnosed over the age of 65 years between 1990 and 2017. The proportion of elderly CD diagnoses increased from 0% in 1990-1991 to 18.7% in 2016-2017 (p
ISSN:2008-2258
2008-4234
DOI:10.22037/ghfbb.v13i1.1845